Microwells with Connecting Channel to Model Metastatic Behavior of Nasopharyngeal Carcinoma Cells

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review

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Detail(s)

Original languageEnglish
Title of host publication22nd International Conference on Solid-State Sensors, Actuators and Microsystems
Number of pages4
Publication statusPublished - Jun 2023

Conference

Title22nd International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS 2023)
LocationKyoto International Conference Center
PlaceJapan
CityKyoto
Period25 - 29 June 2023

Abstract

In this work, three-dimensional microwells with connecting channel were developed for the purpose of investigating traversing behavior of nasopharyngeal carcinoma (NPC43) cells through channels. The structure of these platforms was designed to mimic the extracellular matrix. NPC43 cells are capable of adopting both amoeboid and mesenchymal modes to traverse through narrow channels. With narrower channel widths, the traversing probability of NPC43 cells significantly decreased, as cells need larger morphological deformation to enter narrower channels. Additionally, fibronectin coating on the platforms promoted the NPC43 cell traversing probability. These results are valuable for developing control therapy for nasopharyngeal carcinoma and these platforms can be used as tools for testing the metastasis ability of carcinoma cells.

Research Area(s)

  • Microwells, Connecting Channels, Confinement, Nasopharyngeal Carcinoma Cell Migration

Bibliographic Note

Information for this record is supplemented by the author(s) concerned.

Citation Format(s)

Microwells with Connecting Channel to Model Metastatic Behavior of Nasopharyngeal Carcinoma Cells. / Hong, Xiao; Xu, Yuanhao; Pang, Stella W.
22nd International Conference on Solid-State Sensors, Actuators and Microsystems. 2023.

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review