Microwells with Connecting Channel to Model Metastatic Behavior of Nasopharyngeal Carcinoma Cells
Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Title of host publication | 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. |
| Pages | 1012-1015 |
| Number of pages | 4 |
| ISBN (electronic) | 978-4-88686-435-2 |
| Publication status | Published - Jun 2023 |
Publication series
| Name | International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers |
|---|
Conference
| Title | 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023) |
|---|---|
| Location | Kyoto International Conference Center |
| Place | Japan |
| City | Kyoto |
| Period | 25 - 29 June 2023 |
Link(s)
Abstract
In this work, three-dimensional microwells with connecting channel were developed for the purpose of investigating traversing behavior of nasopharyngeal carcinoma (NPC43) cells through channels. The structure of these platforms was designed to mimic the extracellular matrix. NPC43 cells are capable of adopting both amoeboid and mesenchymal modes to traverse through narrow channels. With narrower channel widths, the traversing probability of NPC43 cells significantly decreased, as cells need larger morphological deformation to enter narrower channels. Additionally, fibronectin coating on the platforms promoted the NPC43 cell traversing probability. These results are valuable for developing control therapy for nasopharyngeal carcinoma and these platforms can be used as tools for testing the metastasis ability of carcinoma cells. © 2023 IEEJ.
Research Area(s)
- Microwells, Connecting Channels, Confinement, Nasopharyngeal Carcinoma Cell Migration
Bibliographic Note
Information for this record is supplemented by the author(s) concerned.
Citation Format(s)
Microwells with Connecting Channel to Model Metastatic Behavior of Nasopharyngeal Carcinoma Cells. / Hong, Xiao; Xu, Yuanhao; Pang, Stella W.
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). Institute of Electrical and Electronics Engineers, Inc., 2023. p. 1012-1015 (International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers).
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). Institute of Electrical and Electronics Engineers, Inc., 2023. p. 1012-1015 (International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers).
Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review
