Microscopic Volta potential difference on metallic surface promotes the osteogenic differentiation and proliferation of human mesenchymal stem cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Shi-Ting Chen
  • Yan Li
  • Si-Yuan He
  • Ping Zhou
  • Ning Gu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number112325
Journal / PublicationMaterials Science and Engineering C
Volume128
Online published16 Jul 2021
Publication statusPublished - Sep 2021

Abstract

Endogenous microscopic electric cues play an essential role in bone's remodeling and self-repair. Modulating the extracellular electrical environment, by means of external electric stimulation or changing surface potential of implants, was manifested to facilitate the osteointegration. The microscopic potential difference, originating from heterogeneous microstructures of materials, may mimic the endogenous electric signals to stimulate surrounding cells. In this study, the spark-plasma sintered Ti/Ta hybrid metal was fabricated and utilized to realize a surface microscopic potential difference at the same magnitude as endogenous potentials. Activated by the electric stimulation, the mesenchymal stem cells exhibited the anisotropic and polygonal cellular morphology on the Ti/Ta hybrid metal. The microscopic electric potential difference coordinated the cells proliferation on the subsequent days. Moreover, the results showed that the osteo-lineage differentiation on Ti/Ta hybrid metal were in vitro boosted over the control groups. Tailoring microstructures of material to obtain a reasonable electric microenvironment may be a necessary principle to achieve more favorable cell responses to implants, suggesting an extra degree of freedom in bone-repairing material design.

Research Area(s)

  • Metal-metal composite, Microscopic Volta potential difference, Osteogenic differentiation, Stem cells, Ti ta hybrid metal

Citation Format(s)

Microscopic Volta potential difference on metallic surface promotes the osteogenic differentiation and proliferation of human mesenchymal stem cells. / Chen, Shi-Ting; Li, Yan; He, Si-Yuan; Zhou, Ping; Lu, Jian; Gu, Ning.

In: Materials Science and Engineering C, Vol. 128, 112325, 09.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review