MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Hongping Xia
  • Yanting Qi
  • Samuel S. Ng
  • Xiaona Chen
  • Shen Chen
  • Marong Fang
  • Dan Li
  • Yu Zhao
  • Ruiguang Ge
  • Guo Li
  • Yangchao Chen
  • Hsiang-fu Kung
  • Lihui Lai
  • Marie C. Lin

Detail(s)

Original languageEnglish
Pages (from-to)205-210
Journal / PublicationBiochemical and Biophysical Research Communications
Volume380
Issue number2
Publication statusPublished - 6 Mar 2009
Externally publishedYes

Abstract

MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules. © 2009 Elsevier Inc. All rights reserved.

Research Area(s)

  • CCNE1, Cell cycle, Glioblastoma, MicroRNA, MiR-15b

Citation Format(s)

MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. / Xia, Hongping; Qi, Yanting; Ng, Samuel S.; Chen, Xiaona; Chen, Shen; Fang, Marong; Li, Dan; Zhao, Yu; Ge, Ruiguang; Li, Guo; Chen, Yangchao; He, Ming-Liang; Kung, Hsiang-fu; Lai, Lihui; Lin, Marie C.

In: Biochemical and Biophysical Research Communications, Vol. 380, No. 2, 06.03.2009, p. 205-210.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review