MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Gang Li
  • Zhengrong Wu
  • Ying Peng
  • Xiong Liu
  • Juan Lu
  • Lu Wang
  • Qiuhui Pan
  • Xiang-Ping Li

Detail(s)

Original languageEnglish
Pages (from-to)29-36
Journal / PublicationCancer Letters
Volume299
Issue number1
Publication statusPublished - 18 Dec 2010
Externally publishedYes

Abstract

MicroRNA-10b (miR-10b) has been reported to facilitate the metastasis of breast cancer. However, little is known about the role of miR-10b in the metastasis of nasopharyngeal carcinoma (NPC). Here, we show that high levels of miR-10b expression in Epstein-Barr virus (EBV)-positive latent membrane protein-1 (LMP1)-expressing NPC cells, and its expression is down-regulated by silencing LMP1 or Twist. Induction of miR-10b over-expression in LMP1-silent C666-1 cells promoted significant wound healing and transmembrane invasiveness in vitro. More importantly, miR-10b over-expression promoted the metastasis of NPC and accelerated the death of tumor-bearing nude mice. These findings strongly suggest that miR-10b positively regulates the metastasis of NPC. © 2010 Elsevier Ireland Ltd.

Research Area(s)

  • Latent membrane protein-1, Metastasis, MiR-10b, Nasopharyngeal carcinoma, Twist

Citation Format(s)

MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells. / Li, Gang; Wu, Zhengrong; Peng, Ying; Liu, Xiong; Lu, Juan; Wang, Lu; Pan, Qiuhui; He, Min-Liang; Li, Xiang-Ping.

In: Cancer Letters, Vol. 299, No. 1, 18.12.2010, p. 29-36.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review