microRNA exchange via extracellular vesicles in cancer
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
---|---|
Article number | e12877 |
Journal / Publication | Cell Proliferation |
Volume | 53 |
Issue number | 11 |
Online published | 6 Oct 2020 |
Publication status | Published - Nov 2020 |
Link(s)
DOI | DOI |
---|---|
Attachment(s) | Documents
Publisher's Copyright Statement
|
Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85095716922&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(7956eb61-605f-4133-8961-2d5600e550fa).html |
Abstract
Cells utilize different means of inter-cellular communication to function properly. Here, we review the crosstalk between cancer cells and their surrounding environment through microRNA (miRNA)-containing extracellular vesicles (EVs). The current findings suggest that the export of miRNAs and uptake of miRNA-containing EVs might be an active process. As post-transcriptional regulators of gene expression, cancer-derived miRNAs that are taken up by normal cells can change the translational profile of the recipient cell towards a transformed proteome. Stromal cells can also deliver miRNAs via EVs to cancer cells to support tumour growth and cancer progression. Therefore, gaining a better understanding of EV-mediated inter-cellular communication in the tumour microenvironment might lead to the development of novel diagnostic and therapeutic strategies.
Research Area(s)
- cancer biology, extracellular vesicles, microRNAs, tumour microenvironment
Citation Format(s)
microRNA exchange via extracellular vesicles in cancer. / Vu, Luyen Tien; Gong, Jinhua; Pham, Thach Tuan; Kim, Yeokyeong; Le, Minh T. N.
In: Cell Proliferation, Vol. 53, No. 11, e12877, 11.2020.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Download Statistics
No data available