microRNA exchange via extracellular vesicles in cancer

Luyen Tien Vu; Jinhua Gong; Thach Tuan Pham; Yeokyeong Kim; Minh T. N. Le

doi:10.1111/cpr.12877

microRNA exchange via extracellular vesicles in cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

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11 Scopus Citations

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Detail(s)

Original language	English
Article number	e12877
Journal / Publication	Cell Proliferation
Volume	53
Issue number	11
Online published	6 Oct 2020
Publication status	Published - Nov 2020

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DOI	DOI https://doi.org/10.1111/cpr.12877 Final Published version
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Attachment(s)	Documents 48650363.pdf Final Published version, 984 KB, PDF Publisher's Copyright Statement This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85095716922&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(7956eb61-605f-4133-8961-2d5600e550fa).html

Abstract

Cells utilize different means of inter-cellular communication to function properly. Here, we review the crosstalk between cancer cells and their surrounding environment through microRNA (miRNA)-containing extracellular vesicles (EVs). The current findings suggest that the export of miRNAs and uptake of miRNA-containing EVs might be an active process. As post-transcriptional regulators of gene expression, cancer-derived miRNAs that are taken up by normal cells can change the translational profile of the recipient cell towards a transformed proteome. Stromal cells can also deliver miRNAs via EVs to cancer cells to support tumour growth and cancer progression. Therefore, gaining a better understanding of EV-mediated inter-cellular communication in the tumour microenvironment might lead to the development of novel diagnostic and therapeutic strategies.