Microneedle biomedical devices

Mengjia Zheng; Tao Sheng; Jicheng Yu; Zhen Gu; Chenjie Xu

doi:10.1038/s44222-023-00141-6

Microneedle biomedical devices

Mengjia Zheng, Tao Sheng, Jicheng Yu^*, Zhen Gu^*, Chenjie Xu^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

147 Citations (Scopus)

716 Downloads (CityUHK Scholars)

Abstract

Microneedle (MN) technologies have gained interest for biomedical applications, ranging from drug delivery to sensing and tissue sampling in skin and internal organs. The microscale feature of MN systems allows the accommodation of therapeutics from small drugs to macromolecule biologics and even living cells. Additionally, it permits body fluid extraction when inserted into tissues. The integration of MNs with other technologies, such as stimuli-responsive materials, smart electronics and wearables, facilitates precision drug delivery, dynamic monitoring and closed-loop theranostic functions. In this Review, we discuss MN materials, structures and engineering approaches, focusing on the integration of MNs with biomedical devices. Finally, we provide a survey on clinical applications of MNs and discuss opportunities and challenges for the translation and commercialization of MNs as biomedical devices.

Original language	English
Pages (from-to)	324-342
Journal	Nature Reviews Bioengineering
Volume	2
Issue number	4
Online published	21 Dec 2023
DOIs	https://doi.org/10.1038/s44222-023-00141-6
Publication status	Published - Apr 2024

Funding

C.X. acknowledges support by Strategic Interdisciplinary Research Grant (7020029) from City University of Hong Kong, General Research Fund (CityU11200820, CityU11202222, CityU11100323) and Collaborative Research Fund (C5044-21G) from the Research Grants Council (RGC) of the Hong Kong Special Administrative Region China, and the Mainland/Hong Kong Joint Research Scheme sponsored by the RGC Hong Kong and the National Natural Science Foundation of China (N_CityU118/20). Z.G. acknowledges support by Zhejiang Province “Kunpeng Action” Plan, National Natural Science Foundation of China (52233013) and National Key R&D Program of China (2021YFA0909900).

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s44222-023-00141-6.

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2 Finished
3 Active

GRF: Absorbent Microarray Eye Patches for Tear Collection & Analysis
XU, C. (Principal Investigator / Project Coordinator) & LAKSHMINARAYANAN, R. (Co-Investigator)
1/01/24 → …
Project: Research
GRF: The Second Generation of Cryomicroneedles for Transdermal Cell Delivery in Cancer Immunotherapy
XU, C. (Principal Investigator / Project Coordinator) & Cheung, A. K. L. (Co-Investigator)
1/01/23 → …
Project: Research
CRF-ExtU-Lead: Development of High-resolution 3D Scaffolds with Biomimetic Triply Periodic Minimal Surface Structure for Bone Tissue Repair
Zhao, X. (Main Project Coordinator [External]) & XU, C. (Principal Investigator / Project Coordinator)
15/04/22 → …
Project: Research

Cite this

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title = "Microneedle biomedical devices",

abstract = "Microneedle (MN) technologies have gained interest for biomedical applications, ranging from drug delivery to sensing and tissue sampling in skin and internal organs. The microscale feature of MN systems allows the accommodation of therapeutics from small drugs to macromolecule biologics and even living cells. Additionally, it permits body fluid extraction when inserted into tissues. The integration of MNs with other technologies, such as stimuli-responsive materials, smart electronics and wearables, facilitates precision drug delivery, dynamic monitoring and closed-loop theranostic functions. In this Review, we discuss MN materials, structures and engineering approaches, focusing on the integration of MNs with biomedical devices. Finally, we provide a survey on clinical applications of MNs and discuss opportunities and challenges for the translation and commercialization of MNs as biomedical devices.",

author = "Mengjia Zheng and Tao Sheng and Jicheng Yu and Zhen Gu and Chenjie Xu",

year = "2024",

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AU - Zheng, Mengjia

AU - Sheng, Tao

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AU - Xu, Chenjie

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N2 - Microneedle (MN) technologies have gained interest for biomedical applications, ranging from drug delivery to sensing and tissue sampling in skin and internal organs. The microscale feature of MN systems allows the accommodation of therapeutics from small drugs to macromolecule biologics and even living cells. Additionally, it permits body fluid extraction when inserted into tissues. The integration of MNs with other technologies, such as stimuli-responsive materials, smart electronics and wearables, facilitates precision drug delivery, dynamic monitoring and closed-loop theranostic functions. In this Review, we discuss MN materials, structures and engineering approaches, focusing on the integration of MNs with biomedical devices. Finally, we provide a survey on clinical applications of MNs and discuss opportunities and challenges for the translation and commercialization of MNs as biomedical devices.

AB - Microneedle (MN) technologies have gained interest for biomedical applications, ranging from drug delivery to sensing and tissue sampling in skin and internal organs. The microscale feature of MN systems allows the accommodation of therapeutics from small drugs to macromolecule biologics and even living cells. Additionally, it permits body fluid extraction when inserted into tissues. The integration of MNs with other technologies, such as stimuli-responsive materials, smart electronics and wearables, facilitates precision drug delivery, dynamic monitoring and closed-loop theranostic functions. In this Review, we discuss MN materials, structures and engineering approaches, focusing on the integration of MNs with biomedical devices. Finally, we provide a survey on clinical applications of MNs and discuss opportunities and challenges for the translation and commercialization of MNs as biomedical devices.

U2 - 10.1038/s44222-023-00141-6

DO - 10.1038/s44222-023-00141-6

M3 - RGC 21 - Publication in refereed journal

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VL - 2

SP - 324

EP - 342

JO - Nature Reviews Bioengineering

JF - Nature Reviews Bioengineering

IS - 4

ER -

Microneedle biomedical devices

Abstract

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Projects

GRF: Absorbent Microarray Eye Patches for Tear Collection & Analysis

GRF: The Second Generation of Cryomicroneedles for Transdermal Cell Delivery in Cancer Immunotherapy

CRF-ExtU-Lead: Development of High-resolution 3D Scaffolds with Biomimetic Triply Periodic Minimal Surface Structure for Bone Tissue Repair

Cite this