Micromixing-Enhanced Biosensing of Radioactivity Using Modified Deinococcus Radiodurans in Microfluidics

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)

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Detail(s)

Original languageEnglish
Title of host publicationProceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems
PublisherInstitute of Electrical and Electronics Engineers
Pages14-18
ISBN (Electronic)978-1-7281-1629-7
ISBN (Print)978-1-7281-1630-3
Publication statusPublished - Apr 2019

Publication series

NameInternational Conference on Nano-Micro Engineered and Molecular Systems NEMS
ISSN (Print)2474-3747
ISSN (Electronic)2474-3755

Conference

Title14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2019)
PlaceThailand
CityBangkok
Period11 - 14 April 2019

Abstract

α-radiation is extremely harmful if inhaled or swallowed, as it can be easily cause carcinogenetic or other physiological diseases. Here, we develop a microfluidic radiation biosensing device based on the β-galactosidase generation of genetically modified bacteria Deinococcus Radiodurans PZ0423 (DRPZ423) upon exposure of the radiation. An electrokinetic bacteria trapper is configured to locally aggregate bacteria to enhance the sensitivity. Additionally, a micro-Thick transparent silicone membrane (<20 μm) has been applied to contain the sensing bacteria with only an radiation reduction of <5 %. Moreover, a micro mixer was further integrated to shorten the sensing time and reduce the loss of p-Aminophenol. Altogether, this work has demonstrated a novel microfluidic radiation biosensing technique for achieving reliable α-radiation monitoring.

Research Area(s)

  • ALPHA-PARTICLES

Citation Format(s)

Micromixing-Enhanced Biosensing of Radioactivity Using Modified Deinococcus Radiodurans in Microfluidics. / Lam, Raymond H. W.; Yang, Chengpeng; Li, Vincent W. T.; Huang, Wei.

Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems. Institute of Electrical and Electronics Engineers, 2019. p. 14-18 8915638 (International Conference on Nano-Micro Engineered and Molecular Systems NEMS).

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)