Microfluidics preparation of liposome containing alginate hydrogel microbeads for CEST MRI

P. Xiao; X. Han; J. Huang; J. Li; Raymond H.W. Lam; Kannie W.Y. Chan

Microfluidics preparation of liposome containing alginate hydrogel microbeads for CEST MRI

P. Xiao, X. Han, J. Huang, J. Li, Raymond H.W. Lam, Kannie W.Y. Chan^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Conference Papers › Abstract › peer-review

Abstract

Image-guided cell therapy plays an important role in monitoring and adjusting the treatment regimen. We have demonstrated that cell viability could be monitored by CEST pH-nanosensors in alginate hydrogel microbeads. Here, we investigated the use of microfluidics to generate liposome containing microbeads and examined their CEST properties after loading with the iodine CT contrast agents Iohexol and Iopamiro. We have successfully demonstrated that the microbead size has greatly reduced from 300-400 μm to 20 μm. Moreover, iodine agents loaded liposomal microbeads generated 4% CEST contrast at 4.2 ppm at 3T. These findings demonstrate a robust platform for the fabrication of liposome containing microbeads under CEST MR guidance.

Original language	English
Publication status	Published - May 2019
Event	27th International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2019) - Palais des congrès de Montréal, Montréal, Canada Duration: 11 May 2019 → 16 May 2019 https://www.ismrm.org/19m/

Conference

Conference	27th International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2019)
Abbreviated title	ISMRM 27th Annual Meeting & Exhibition
Place	Canada
City	Montréal
Period	11/05/19 → 16/05/19
Internet address	https://www.ismrm.org/19m/

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@conference{294f33800e1f458bbbccca1236ecedd8,

title = "Microfluidics preparation of liposome containing alginate hydrogel microbeads for CEST MRI",

abstract = "Image-guided cell therapy plays an important role in monitoring and adjusting the treatment regimen. We have demonstrated that cell viability could be monitored by CEST pH-nanosensors in alginate hydrogel microbeads. Here, we investigated the use of microfluidics to generate liposome containing microbeads and examined their CEST properties after loading with the iodine CT contrast agents Iohexol and Iopamiro. We have successfully demonstrated that the microbead size has greatly reduced from 300-400 μm to 20 μm. Moreover, iodine agents loaded liposomal microbeads generated 4% CEST contrast at 4.2 ppm at 3T. These findings demonstrate a robust platform for the fabrication of liposome containing microbeads under CEST MR guidance.",

author = "P. Xiao and X. Han and J. Huang and J. Li and Lam, {Raymond H.W.} and Chan, {Kannie W.Y.}",

year = "2019",

month = may,

language = "English",

note = "27th International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2019), ISMRM 27th Annual Meeting & Exhibition ; Conference date: 11-05-2019 Through 16-05-2019",

url = "https://www.ismrm.org/19m/",

}

TY - CONF

T1 - Microfluidics preparation of liposome containing alginate hydrogel microbeads for CEST MRI

AU - Xiao, P.

AU - Han, X.

AU - Huang, J.

AU - Li, J.

AU - Lam, Raymond H.W.

AU - Chan, Kannie W.Y.

PY - 2019/5

Y1 - 2019/5

N2 - Image-guided cell therapy plays an important role in monitoring and adjusting the treatment regimen. We have demonstrated that cell viability could be monitored by CEST pH-nanosensors in alginate hydrogel microbeads. Here, we investigated the use of microfluidics to generate liposome containing microbeads and examined their CEST properties after loading with the iodine CT contrast agents Iohexol and Iopamiro. We have successfully demonstrated that the microbead size has greatly reduced from 300-400 μm to 20 μm. Moreover, iodine agents loaded liposomal microbeads generated 4% CEST contrast at 4.2 ppm at 3T. These findings demonstrate a robust platform for the fabrication of liposome containing microbeads under CEST MR guidance.

AB - Image-guided cell therapy plays an important role in monitoring and adjusting the treatment regimen. We have demonstrated that cell viability could be monitored by CEST pH-nanosensors in alginate hydrogel microbeads. Here, we investigated the use of microfluidics to generate liposome containing microbeads and examined their CEST properties after loading with the iodine CT contrast agents Iohexol and Iopamiro. We have successfully demonstrated that the microbead size has greatly reduced from 300-400 μm to 20 μm. Moreover, iodine agents loaded liposomal microbeads generated 4% CEST contrast at 4.2 ppm at 3T. These findings demonstrate a robust platform for the fabrication of liposome containing microbeads under CEST MR guidance.

M3 - Abstract

T2 - 27th International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2019)

Y2 - 11 May 2019 through 16 May 2019

ER -

Microfluidics preparation of liposome containing alginate hydrogel microbeads for CEST MRI

Abstract

Conference

Other Access Options

Permanent Link

Fingerprint

Cite this