Microfluidic-based dispenser for sub-microliter pipetting

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Author(s)

Detail(s)

Original languageEnglish
Article number4805432
Pages (from-to)515-518
Journal / PublicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Publication statusPublished - 2009
Externally publishedYes

Conference

Title22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009
PlaceItaly
CitySorrento
Period25 - 29 January 2009

Abstract

In the study, we report a microfluidic-based dispenser fabricated by standard soft lithography of PDMS (polydimethylsiloxane) for sub-microliter range precise pipetting. The key feature of the microfluidic-based dispenser is the incorporation of a pressure-generating unit providing the driving force for precise and quick aqueous liquid sampling and pipetting. The microfluidic-based dispenser features in the elegant control of the releasing time of the air pressure in the pneumatic chamber of the pressure-generating unit causing the underside membrane to provide suction, thus contributing to precise pipetting of aqueous liquid volumes ranging from 0.05 μ1 to 0.45 μ1 (the minimum unit is 0.05 μ1) achieving the multi-volume dispensing capability. Therefore, the developed microfluidic-based dispenser can dispense multiple sub-microliter aqueous liquid volumes precisely and quickly and is promising for further micro-total-analysis-systems in the field of drug dosing orother biomedical applications. ©2009 IEEE.

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