Microfluidic preparation of liposomal hydrogel microbeads containing CT agents (CT-lipobeads) to longitudinally monitor pH using CEST MRI

Research output: Conference PapersRGC 32 - Refereed conference paper (without host publication)peer-review

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Detail(s)

Original languageEnglish
Publication statusPublished - May 2021

Conference

Title2021 International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting
LocationOnline
Period15 - 20 May 2021

Abstract

Iodinated CT contrast agents(CA) had been investigated as CEST contrast agent while high dose of CA and quick clearance could limit their potential for monitoring pH longitudinally. Here, we aim to introduce CT-lipobeads to address this issue. The CT-lipobeads showed 10% CEST contrast and good pH dependency at pH 6.0-7.0, which is sensitive to distinguish hypoxic medium from normoxic medium. Moreover, CT-lipobeads generated CEST contrast of 9% in the subcutaneous compartment, and contrast remained constant over a week. These fndings demonstrated a robust approach for fabrication of CT-lipobeads with decent CEST contrast for longitudinal pH imaging.

Citation Format(s)

Microfluidic preparation of liposomal hydrogel microbeads containing CT agents (CT-lipobeads) to longitudinally monitor pH using CEST MRI. / Xiao, Peng; Huang, Jianpan; Han, Xiongqi et al.
2021. Paper presented at 2021 International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting.

Research output: Conference PapersRGC 32 - Refereed conference paper (without host publication)peer-review