Microfluidic devices for circulating tumor cells isolation and subsequent analysis

Avid Khamenehfar; Paul C.H. Li

doi:10.2174/1389201017666160301103509

Author(s)

Avid Khamenehfar
Paul C.H. Li

Detail(s)

Original language	English
Pages (from-to)	810-821
Journal / Publication	Current Pharmaceutical Biotechnology
Volume	17
Issue number	9
Publication status	Published - 1 Jul 2016
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.2174/1389201017666160301103509 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84975780279&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(cf6be12e-7d2c-4df7-8df8-89a3a04a139f).html

Abstract

The research of circulating tumor cells (CTCs) has drawn much attention in recent years. It is because of the potential values of CTCs in early diagnosis of cancer, management of clinical treatment, exploration of metastatic mechanism, and development of personalized medicine. However, isolating CTCs has been technically challenging due to their rare numbers in blood. Recently, a variety of microfluidic devices have been developed for CTC isolation, and these devices can realize high capture efficiency and high purity. While enumeration of CTCs has been achieved, further cellular and DNA analysis on the captured CTCs are less reported. In this article, we review recent reports in microfluidic methods for isolation of CTCs and subsequent cellular analysis on them.

Research Area(s)

Circulating tumor cell, Dielectrophoresis, Immunoaffinity, Immunomagnetic, Microfluidics, Size-based separation

SDG 3 - Good Health and Well-being

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Citation Format(s)

[ RIS ] [ BibTeX ]

Microfluidic devices for circulating tumor cells isolation and subsequent analysis. / Khamenehfar, Avid; Li, Paul C.H.
In: Current Pharmaceutical Biotechnology, Vol. 17, No. 9, 01.07.2016, p. 810-821.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Khamenehfar, A & Li, PCH 2016, 'Microfluidic devices for circulating tumor cells isolation and subsequent analysis', Current Pharmaceutical Biotechnology, vol. 17, no. 9, pp. 810-821. https://doi.org/10.2174/1389201017666160301103509

Khamenehfar, A., & Li, P. C. H. (2016). Microfluidic devices for circulating tumor cells isolation and subsequent analysis. Current Pharmaceutical Biotechnology, 17(9), 810-821. https://doi.org/10.2174/1389201017666160301103509

Khamenehfar A, Li PCH. Microfluidic devices for circulating tumor cells isolation and subsequent analysis. Current Pharmaceutical Biotechnology. 2016 Jul 1;17(9):810-821. doi: 10.2174/1389201017666160301103509

Khamenehfar, Avid ; Li, Paul C.H. / Microfluidic devices for circulating tumor cells isolation and subsequent analysis. In: Current Pharmaceutical Biotechnology. 2016 ; Vol. 17, No. 9. pp. 810-821.