Microfluidic Blood Plasma Extractor From Whole Blood Sample

Hogi Hartanto; Ting-Hsuan Chen

Microfluidic Blood Plasma Extractor From Whole Blood Sample

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

1 Citation (Scopus)

Abstract

This paper reports on a point-of-care (POC) microfluidic device for separation and extraction of blood plasma from whole blood samples. Designed to be accessible for any kind of setting, the device works by utilizing sequential capillary draining to extract blood plasma through a membrane when a working fluid is introduced in the manifold inlet. Utilizing a combination of a simple membrane and geometrical design without an external power source, this self-driven capillary device can obtain approximately 50% of the original volume of whole blood, suggesting a complete extraction readily available for integration with a POC detection and a 99.9% filtration of red and white blood cells without rupturing due to capillary-based filtration. © 2023 IEEJ.

Original language	English
Title of host publication	2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)
Publisher	IEEE
Pages	1058-1061
ISBN (Electronic)	978-4-88686-435-2
ISBN (Print)	979-8-3503-3302-2
Publication status	Published - 2023
Event	22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023) - Kyoto International Conference Center, Kyoto, Japan Duration: 25 Jun 2023 → 29 Jun 2023 https://transducers2023.org/

Publication series

Name	International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers
ISSN (Print)	2167-0013
ISSN (Electronic)	2167-0021

Conference

Conference	22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023)
Abbreviated title	Transducers2023
Place	Japan
City	Kyoto
Period	25/06/23 → 29/06/23
Internet address	https://transducers2023.org/

Funding

We thank Dr. Ayokunle Olanrewaju (University of Washington) and Prof. David Juncker (McGill University) for providing us with more insight on the sequential draining method. We are also pleased to acknowledge the funding support from Hong Kong Research Grant Council (11217820 and N_CityU119/19), The Science, Technology and Innovation Commission of Shenzhen Municipality, (JCYJ20210324134006017) and City University of Hong Kong (9678242, 6430620, and 7020072).

Research Keywords

Blood plasma extraction
microfluidics
point-of-care devices
sequential draining

RGC Funding Information

RGC-funded

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https://ieeexplore.ieee.org/document/10516756

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Check CityUHK Library

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Cite this

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title = "Microfluidic Blood Plasma Extractor From Whole Blood Sample",

abstract = "This paper reports on a point-of-care (POC) microfluidic device for separation and extraction of blood plasma from whole blood samples. Designed to be accessible for any kind of setting, the device works by utilizing sequential capillary draining to extract blood plasma through a membrane when a working fluid is introduced in the manifold inlet. Utilizing a combination of a simple membrane and geometrical design without an external power source, this self-driven capillary device can obtain approximately 50% of the original volume of whole blood, suggesting a complete extraction readily available for integration with a POC detection and a 99.9% filtration of red and white blood cells without rupturing due to capillary-based filtration. {\textcopyright} 2023 IEEJ.",

keywords = "Blood plasma extraction, microfluidics, point-of-care devices, sequential draining",

author = "Hogi Hartanto and Ting-Hsuan Chen",

year = "2023",

language = "English",

isbn = "979-8-3503-3302-2",

series = "International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers",

publisher = "IEEE",

pages = "1058--1061",

booktitle = "2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)",

address = "United States",

note = "22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023), Transducers2023 ; Conference date: 25-06-2023 Through 29-06-2023",

url = "https://transducers2023.org/",

}

Hartanto, H & Chen, T-H 2023, Microfluidic Blood Plasma Extractor From Whole Blood Sample. in 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers, IEEE, pp. 1058-1061, 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023), Kyoto, Japan, 25/06/23. <https://ieeexplore.ieee.org/document/10516756>

Microfluidic Blood Plasma Extractor From Whole Blood Sample. / Hartanto, Hogi ; Chen, Ting-Hsuan.
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). IEEE, 2023. p. 1058-1061 (International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Microfluidic Blood Plasma Extractor From Whole Blood Sample

AU - Hartanto, Hogi

AU - Chen, Ting-Hsuan

PY - 2023

Y1 - 2023

N2 - This paper reports on a point-of-care (POC) microfluidic device for separation and extraction of blood plasma from whole blood samples. Designed to be accessible for any kind of setting, the device works by utilizing sequential capillary draining to extract blood plasma through a membrane when a working fluid is introduced in the manifold inlet. Utilizing a combination of a simple membrane and geometrical design without an external power source, this self-driven capillary device can obtain approximately 50% of the original volume of whole blood, suggesting a complete extraction readily available for integration with a POC detection and a 99.9% filtration of red and white blood cells without rupturing due to capillary-based filtration. © 2023 IEEJ.

AB - This paper reports on a point-of-care (POC) microfluidic device for separation and extraction of blood plasma from whole blood samples. Designed to be accessible for any kind of setting, the device works by utilizing sequential capillary draining to extract blood plasma through a membrane when a working fluid is introduced in the manifold inlet. Utilizing a combination of a simple membrane and geometrical design without an external power source, this self-driven capillary device can obtain approximately 50% of the original volume of whole blood, suggesting a complete extraction readily available for integration with a POC detection and a 99.9% filtration of red and white blood cells without rupturing due to capillary-based filtration. © 2023 IEEJ.

KW - Blood plasma extraction

KW - microfluidics

KW - point-of-care devices

KW - sequential draining

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M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 979-8-3503-3302-2

T3 - International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers

SP - 1058

EP - 1061

BT - 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)

PB - IEEE

T2 - 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2023)

Y2 - 25 June 2023 through 29 June 2023

ER -

Microfluidic Blood Plasma Extractor From Whole Blood Sample

Abstract

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Conference

Funding

Research Keywords

RGC Funding Information

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GRF: Engineering Functional Skeletal Muscle Sheets for Bionic Applications

NSFC: Exploration of Cell Chirality Using Material Surface Patterning

Cite this

Microfluidic Blood Plasma Extractor From Whole Blood Sample

Abstract

Publication series

Conference

Funding

Research Keywords

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

GRF: Engineering Functional Skeletal Muscle Sheets for Bionic Applications

NSFC: Exploration of Cell Chirality Using Material Surface Patterning

Cite this