Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

8 Scopus Citations
View graph of relations

Author(s)

  • Zhenkun Na
  • Jiaqi Fu
  • Chelsea Y. J Tan
  • Huatang Zhang
  • Shao Q. Yao

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)11818-11821
Journal / PublicationChemical communications (Cambridge, England)
Volume50
Issue number80
Online published14 Jul 2014
Publication statusPublished - 14 Oct 2014

Abstract

By anchoring 1,2,4,5-tetrazine-containing biomolecules onto trans-cyclooctene (TCO)-functionalized slides, a site-specific microarray immobilization approach is described in this study. Compared with existing immobilization methods, our approach offers several distinctive features, including fast kinetics and high chemoselectivity.

Citation Format(s)

Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction. / Wang, Ping; Na, Zhenkun; Fu, Jiaqi; Tan, Chelsea Y. J; Zhang, Huatang; Yao, Shao Q.; Sun, Hongyan.

In: Chemical communications (Cambridge, England), Vol. 50, No. 80, 14.10.2014, p. 11818-11821.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal