Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction

Ping Wang; Zhenkun Na; Jiaqi Fu; Chelsea Y. J Tan; Huatang Zhang; Shao Q. Yao; Hongyan Sun

doi:10.1039/c4cc03838j

Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction

Ping Wang
, Zhenkun Na
, Jiaqi Fu
, Chelsea Y. J Tan
, Huatang Zhang
, Shao Q. Yao
, Hongyan Sun

CityUHK Shenzhen Research Institute

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

21 Citations (Scopus)

Abstract

By anchoring 1,2,4,5-tetrazine-containing biomolecules onto trans-cyclooctene (TCO)-functionalized slides, a site-specific microarray immobilization approach is described in this study. Compared with existing immobilization methods, our approach offers several distinctive features, including fast kinetics and high chemoselectivity.

Original language	English
Pages (from-to)	11818-11821
Journal	Chemical communications (Cambridge, England)
Volume	50
Issue number	80
Online published	14 Jul 2014
DOIs	https://doi.org/10.1039/c4cc03838j
Publication status	Published - 14 Oct 2014

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title = "Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction",

abstract = "By anchoring 1,2,4,5-tetrazine-containing biomolecules onto trans-cyclooctene (TCO)-functionalized slides, a site-specific microarray immobilization approach is described in this study. Compared with existing immobilization methods, our approach offers several distinctive features, including fast kinetics and high chemoselectivity.",

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TY - JOUR

T1 - Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction

AU - Wang, Ping

AU - Na, Zhenkun

AU - Fu, Jiaqi

AU - Tan, Chelsea Y. J

AU - Zhang, Huatang

AU - Yao, Shao Q.

AU - Sun, Hongyan

PY - 2014/10/14

Y1 - 2014/10/14

N2 - By anchoring 1,2,4,5-tetrazine-containing biomolecules onto trans-cyclooctene (TCO)-functionalized slides, a site-specific microarray immobilization approach is described in this study. Compared with existing immobilization methods, our approach offers several distinctive features, including fast kinetics and high chemoselectivity.

AB - By anchoring 1,2,4,5-tetrazine-containing biomolecules onto trans-cyclooctene (TCO)-functionalized slides, a site-specific microarray immobilization approach is described in this study. Compared with existing immobilization methods, our approach offers several distinctive features, including fast kinetics and high chemoselectivity.

UR - https://www.scopus.com/pages/publications/84907148368

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84907148368&origin=recordpage

U2 - 10.1039/c4cc03838j

DO - 10.1039/c4cc03838j

M3 - RGC 21 - Publication in refereed journal

C2 - 25052778

SN - 1364-548X

VL - 50

SP - 11818

EP - 11821

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 80

ER -

Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction

Abstract

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