Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier

Pan Jie; Subbu S. Venkatraman; Feng Min; Yin Chiang Freddy Boey; Gan Leong Huat

doi:10.1016/j.jconrel.2005.09.011

Author(s)

Pan Jie
Subbu S. Venkatraman
Feng Min
Yin Chiang Freddy Boey
Gan Leong Huat

Detail(s)

Original language	English
Pages (from-to)	20-33
Journal / Publication	Journal of Controlled Release
Volume	110
Issue number	1
Online published	11 Nov 2005
Publication status	Published - 10 Dec 2005
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.jconrel.2005.09.011 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-28244443572&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(2d78f1af-bbd5-4a10-86ee-a772c3ddc23c).html

Abstract

Four-armed (star-branched) block copolymers of l-PLA and PEO were synthesized using ring opening polymerization with different LA / EO ratio. Micellar aggregates were prepared from these block copolymers and characterized. Some surface segregation of PEG was found : the extent depends on the state of the material (whether it is in film or particle form), as well as on molecular geometry. The degradation behavior of star-shaped copolymer was studied over a three week period and compared to its linear counterpart. Anti-cancer drugs 5-FU and paclitaxel were loaded into the micellar nanoparticles. The drug release profile showed that the release of paclitaxel from these polymers could be controlled over 2 weeks. The kinetics of drug release for star-branched, tri- and di-block copolymers were compared. The micelles from star-shaped branch showed more complete release of drug than the diblock copolymers; also, the lower hydrodynamic radius of star-shaped polymers may result in better clearance of the carrier polymer from the body. © 2005 Elsevier B.V. All rights reserved.

Research Area(s)

5-FU, Drug carrier, Paclitaxel, PEO, PLA

SDG 3 - Good Health and Well-being

Citation Format(s)

[ RIS ] [ BibTeX ]

Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier. / Jie, Pan; Venkatraman, Subbu S.; Min, Feng et al.
In: Journal of Controlled Release, Vol. 110, No. 1, 10.12.2005, p. 20-33.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Jie, P, Venkatraman, SS, Min, F, Boey, YCF & Huat, GL 2005, 'Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier', Journal of Controlled Release, vol. 110, no. 1, pp. 20-33. https://doi.org/10.1016/j.jconrel.2005.09.011

Jie, P., Venkatraman, S. S., Min, F., Boey, Y. C. F., & Huat, G. L. (2005). Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier. Journal of Controlled Release, 110(1), 20-33. https://doi.org/10.1016/j.jconrel.2005.09.011

Jie P, Venkatraman SS, Min F, Boey YCF, Huat GL. Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier. Journal of Controlled Release. 2005 Dec 10;110(1):20-33. Epub 2005 Nov 11. doi: 10.1016/j.jconrel.2005.09.011

Jie, Pan ; Venkatraman, Subbu S. ; Min, Feng et al. / Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier. In: Journal of Controlled Release. 2005 ; Vol. 110, No. 1. pp. 20-33.