Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Guanghui Wang
  • Haifeng Chen
  • Minghui Huang
  • Naili Wang
  • Jinchao Zhang
  • Yaou Zhang
  • Ganrong Bai
  • Wang-Fun Fong
  • Xinsheng Yao

Detail(s)

Original languageEnglish
Pages (from-to)102-109
Journal / PublicationCancer Letters
Volume241
Issue number1
Publication statusPublished - 8 Sep 2006

Abstract

Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent. © 2006 Elsevier Ireland Ltd.

Research Area(s)

  • Apoptosis, G2/M arrest, Methyl protodioscin

Citation Format(s)

Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. / Wang, Guanghui; Chen, Haifeng; Huang, Minghui; Wang, Naili; Zhang, Jinchao; Zhang, Yaou; Bai, Ganrong; Fong, Wang-Fun; Yang, Mengsu; Yao, Xinsheng.

In: Cancer Letters, Vol. 241, No. 1, 08.09.2006, p. 102-109.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review