Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Article number194
Journal / PublicationInternational Journal of Molecular Sciences
Volume17
Issue number2
Online published2 Feb 2016
Publication statusPublished - Feb 2016
Externally publishedYes

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Abstract

Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.

Research Area(s)

  • antibody-drug conjugates (ADCs), targeted therapy, monoclonal antibodies (mAbs), drugs, linkers

Citation Format(s)

Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs). / Yao, Houzong; Jiang, Feng; Lu, Aiping et al.
In: International Journal of Molecular Sciences, Vol. 17, No. 2, 194, 02.2016.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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