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Metasurface-Based Abrupt Autofocusing Beam for Biomedical Applications

  • Yuan Luo* (Co-first Author)
  • , Ming Lun Tseng (Co-first Author)
  • , Sunil Vyas (Co-first Author)
  • , Hsin Yu Kuo (Co-first Author)
  • , Cheng Hung Chu
  • , Mu Ku Chen
  • , Hsiang-Chieh Lee
  • , Wen-Pin Chen
  • , Vin-Cent Su
  • , Xu Shi
  • , Hiroaki Misawa
  • , Din Ping Tsai*
  • , Pan-Chyr Yang*
    • *Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

Manipulation and precise delivery of optical energies in the regions of interest within specimens require different strategies. Hence, proper control of input beam parameters is a prerequisite. One of the prominent methods is metasurface optics, capable of crafting properties of light at nanoscales. Here, the generation of an abrupt autofocusing (AAF) beam by a nanophotonic metasurface for biomedical applications is demonstrated. Fluorescence guided laser microprofiling of mouse cardiac samples is experimentally investigated, using the AAF beam to deliver optical energy selectively to specific locations. In addition, photocoagulation of ex vivo swine skin tissue is performed and observed through optical coherence tomography. The results show great potentials for integrating metasurface optics to realize miniature laser surgery instruments for wide applications in biomedicine.
Original languageEnglish
Article number2101228
JournalSmall Methods
Volume6
Issue number4
Online published24 Feb 2022
DOIs
Publication statusPublished - 20 Apr 2022

Funding

The authors acknowledge financial support from the Ministry of Science and Technology, Taiwan (Grant Nos. MOST-106-2221-E-002-157-MY3 and MOST-108-2221-E-002-168-MY4), National Taiwan University (Grant Nos. NTU-107L7728, NTU-107L7807 and NTU-YIH-08HZT49001), the University Grants Committee / Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. AoE/P-502/20 and GRF Project: 15303521), the Shenzhen Science and Technology Innovation Commission (Grant No. SGDX2019081623281169), the Department of Science and Technology of Guangdong Province (Grant No. 2020B1515120073), the City University of Hong Kong (Grant No. 9380131), and JSPS KAKENHI (Grant No. JP18H05205).

Research Keywords

  • abrupt autofocusing beam
  • laser surgery
  • metasurfaces

Publisher's Copyright Statement

  • This full text is made available under CC-BY-NC-ND 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/

RGC Funding Information

  • RGC-funded

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