Metalated Chromene and Chromone Complexes : pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

8 Scopus Citations
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Author(s)

  • Lai-Hon Chung
  • Hau-Lam Shek
  • Tian-Shu Kang
  • Chung-Hang Leung
  • Dik-Lung Ma

Detail(s)

Original languageEnglish
Pages (from-to)1779-1783
Journal / PublicationChemistry - A European Journal
Volume24
Issue number8
Online published7 Dec 2017
Publication statusPublished - 6 Feb 2018

Abstract

The two families of RuII-chromene and -chromone complexes isolated in this work represent the first examples of metalated chromene and chromone complexes synthesized through transition-metal-mediated cyclization of phenol-tethered ynone. These unprecedented metalated heterocyclic compounds exhibit remarkable features, such as pH-switchable metal–carbon bonding interactions, photo-triggerable release of organic chromone upon visible-light irradiation, and superior antioxidative property to their organic analogue (1,4-benzopyrone). These findings not only offer mechanistic insights into metal-induced activation of functionalized alkynes, but also add a new dimension to rational design of antioxidants and photo-responsive drug delivery systems.

Research Area(s)

  • alkynes, antioxidants, chromones, photochemistry, ruthenium

Citation Format(s)

Metalated Chromene and Chromone Complexes : pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity. / Ng, Sze-Wing; Chung, Lai-Hon; Yeung, Chi-Fung; Lo, Hoi-Shing; Shek, Hau-Lam; Kang, Tian-Shu; Leung, Chung-Hang; Ma, Dik-Lung; Wong, Chun-Yuen.

In: Chemistry - A European Journal, Vol. 24, No. 8, 06.02.2018, p. 1779-1783.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal