Metalated Chromene and Chromone Complexes : pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Overview

10 Scopus Citations

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Author(s)

Lai-Hon Chung
Hau-Lam Shek
Tian-Shu Kang
Chung-Hang Leung
Dik-Lung Ma

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	1779-1783
Journal / Publication	Chemistry - A European Journal
Volume	24
Issue number	8
Online published	7 Dec 2017
Publication status	Published - 6 Feb 2018

Link(s)

DOI	DOI https://doi.org/10.1002/chem.201705450 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85041587808&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(af2a811c-438e-4c18-b5c0-d829a3a6e37a).html

Abstract

The two families of Ru^II-chromene and -chromone complexes isolated in this work represent the first examples of metalated chromene and chromone complexes synthesized through transition-metal-mediated cyclization of phenol-tethered ynone. These unprecedented metalated heterocyclic compounds exhibit remarkable features, such as pH-switchable metal–carbon bonding interactions, photo-triggerable release of organic chromone upon visible-light irradiation, and superior antioxidative property to their organic analogue (1,4-benzopyrone). These findings not only offer mechanistic insights into metal-induced activation of functionalized alkynes, but also add a new dimension to rational design of antioxidants and photo-responsive drug delivery systems.

Research Area(s)

alkynes, antioxidants, chromones, photochemistry, ruthenium

Citation Format(s)

[ RIS ] [ BibTeX ]

Metalated Chromene and Chromone Complexes : pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity. / Ng, Sze-Wing; Chung, Lai-Hon; Yeung, Chi-Fung ; Lo, Hoi-Shing; Shek, Hau-Lam; Kang, Tian-Shu; Leung, Chung-Hang; Ma, Dik-Lung; Wong, Chun-Yuen.

In: Chemistry - A European Journal, Vol. 24, No. 8, 06.02.2018, p. 1779-1783.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Ng, S-W, Chung, L-H, Yeung, C-F , Lo, H-S, Shek, H-L, Kang, T-S, Leung, C-H, Ma, D-L & Wong, C-Y 2018, 'Metalated Chromene and Chromone Complexes: pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity', Chemistry - A European Journal, vol. 24, no. 8, pp. 1779-1783. https://doi.org/10.1002/chem.201705450

Ng, S-W., Chung, L-H., Yeung, C-F., Lo, H-S., Shek, H-L., Kang, T-S., Leung, C-H., Ma, D-L., & Wong, C-Y. (2018). Metalated Chromene and Chromone Complexes: pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity. Chemistry - A European Journal, 24(8), 1779-1783. https://doi.org/10.1002/chem.201705450

Ng S-W, Chung L-H, Yeung C-F , Lo H-S, Shek H-L, Kang T-S et al. Metalated Chromene and Chromone Complexes: pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity. Chemistry - A European Journal. 2018 Feb 6;24(8):1779-1783. https://doi.org/10.1002/chem.201705450

Ng, Sze-Wing ; Chung, Lai-Hon ; Yeung, Chi-Fung ; Lo, Hoi-Shing ; Shek, Hau-Lam ; Kang, Tian-Shu ; Leung, Chung-Hang ; Ma, Dik-Lung ; Wong, Chun-Yuen. / Metalated Chromene and Chromone Complexes : pH Switchable Metal–Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity. In: Chemistry - A European Journal. 2018 ; Vol. 24, No. 8. pp. 1779-1783.