Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

View graph of relations

Author(s)

  • Pan Li
  • Binbin Zhou
  • Meihong Ge
  • Xianghong Jing
  • Liangbao Yang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number122913
Journal / PublicationTalanta
Volume237
Online published1 Oct 2021
Publication statusPublished - 15 Jan 2022

Abstract

Sensitivity and credibility detecting histamine (HA) as an important neurotransmitter in biofluids is of importance in analytical science and physiology. Surface-enhanced Raman spectroscopy (SERS) is able to realize the high sensitivity with single molecules level, but providing the high sensitivity for HA with a small cross section remains a challenge. Here we develop the metal complex-based SERS nanoprobe nitrilotriacetic acid-Ni2+ (NTA-Ni2+) combined with self-assemble Au NPs active substrates for sensitive detection of HA. The NTA-Ni2+ can capture the HA molecules close to Au NPs substrates and then amplify the Raman signals of HA owing to the formation of a complex of NTA-Ni2+-HA. The self-assemble Au film through the evaporation-driven method can provide the high-density hot spots substrate with high stability and reproducibility. The NTA-Ni2+ decorated Au NPs as nanoprobe responds to HA with 1 μM level of sensitivity. More importantly, the developed SERS nanoprobe composing of NTA-Ni2+ and self-assemble Au NPs can be utilized to detect and monitor the HA spiked into serum, indicating the potential prospect in analysis of HA in complex specimen.

Research Area(s)

  • Histamine, Metal coordination, Neurotransmitter, SERS, SERS nanoprobe

Citation Format(s)

Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum. / Li, Pan; Zhou, Binbin; Ge, Meihong; Jing, Xianghong; Yang, Liangbao.

In: Talanta, Vol. 237, 122913, 15.01.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review