Metabolomic analysis reveals metabolic alterations of human peripheral blood lymphocytes by perfluorooctanoic acid

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Rong Li
  • Chao Guo
  • William Ka Fai Tse
  • Min Su
  • Xiaoxi Zhang
  • And 1 others
  • Keng Po Lai

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number124810
Journal / PublicationChemosphere
Volume239
Online published7 Sept 2019
Publication statusPublished - Jan 2020

Abstract

Perfluorooctanoic acid (PFOA) is a dispersive persistent organic pollutant in the environment. Accumulating reports suggest that PFOA is toxic to human lymphocytes; however, the toxicological effects of PFOA on these cells remain largely unclear. In this study, ultra-performance liquid chromatography (UPLC)-based metabolomic analysis was employed to identify metabolites in human peripheral blood lymphocytes and to assess the metabolic alterations caused by PFOA exposure. Our comparative metabolomic analysis results demonstrated that PFOA treatment could increase the level of organic acids and reduce the level of lipid molecules. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation further highlighted the fact that the PFOA treatment interfered with the metabolism of amino acids, carbohydrates and lipids, which may lead to disruption of the immune system.

Research Area(s)

  • Lymphocytes, Metabolism, Metabolomics, Perfluorooctanoic acid

Citation Format(s)

Metabolomic analysis reveals metabolic alterations of human peripheral blood lymphocytes by perfluorooctanoic acid. / Li, Rong; Guo, Chao; Tse, William Ka Fai et al.
In: Chemosphere, Vol. 239, 124810, 01.2020.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review