Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain : Proton magnetic resonance spectroscopy study at 3 T

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

26 Scopus Citations
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Author(s)

  • Pui-Wai Chiu
  • Henry Ka-Fung Mak
  • Queenie Chan
  • Raymond Chuen-Chung Chang
  • Leung-Wing Chu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)251-264
Journal / PublicationAge
Volume36
Issue number1
Online published26 May 2013
Publication statusPublished - Feb 2014

Abstract

Magnetic resonance spectroscopy (MRS) can explore aging at a molecular level. In this study, we investigated the relationships between regional concentrations of metabolites (such as choline, creatine, myo-inositol, and N-acetyl-aspartate) and normal aging in 30 cognitively normal subjects (15 women and 15 men, age range 22- 82, mean=49.9±18.3 years) using quantitative proton magnetic resonance spectroscopy. All MR scans were performed using a 3 T scanner. Point resolved spectroscopy was used as the volume selection method for the region-of-interest and the excitation method for water suppression. Single voxel spectroscopy with short echo time of 39 ms and repetition time of 2,000 ms was employed. Single voxels were placed in the limbic regions, i.e., anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and left and right hippocampi. Cerebrospinal fluid normalization and T1 and T2 correction factors were implemented in the calculation of absolute metabolite concentrations. A standardized T1W 3D volumetric fast field echo and axial T2-weighted fast spin-echo images were also acquired. Our results showed significant positive correlation of choline (r=0.545, p=0.002), creatine (r=0.571, p=0.001), and N-acetyl-aspartate (r= 0.674, p

Research Area(s)

  • Absolute quantification, Aging, Anterior cingulate cortex, Magnetic resonance spectroscopy, Neuronal hypertrophy, Posterior cingulate cortex

Citation Format(s)

Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain : Proton magnetic resonance spectroscopy study at 3 T. / Chiu, Pui-Wai; Mak, Henry Ka-Fung; Yau, Kelvin Kai-Wing; Chan, Queenie; Chang, Raymond Chuen-Chung; Chu, Leung-Wing.

In: Age, Vol. 36, No. 1, 02.2014, p. 251-264.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review