Met exon 14 skipping in non-small cell lung cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

35 Scopus Citations
View graph of relations

Author(s)

  • Rebecca S. Heist
  • Hyo Sup Shim
  • Shalini Gingipally
  • Mari Mino-Kenudson
  • Long Le
  • Justin F. Gainor
  • Martin Aryee
  • Junfeng Xia
  • Peilin Jia
  • Hailing Jin
  • Zhongming Zhao
  • William Pao
  • Jeffrey A. Engelman
  • A. John Iafrate

Detail(s)

Original languageEnglish
Pages (from-to)481-486
Journal / PublicationOncologist
Volume21
Issue number4
Publication statusPublished - 1 Apr 2016
Externally publishedYes

Abstract

Background. Non-small cell lung cancers (NSCLCs) harboring specific genetic alterations can be highly sensitive to targeted therapies. Material sand Methods. We performed a targeted rearrangement assay on 54 NSCLCs across all stages that were from patients who were never smokers and did not have driver mutations. Because MET exon 14 skipping was the most frequent alteration found, we surveyed the results for MET exon 14 skipping at Massachusetts General Hospital (MGH) since the inclusion of this alteration into our current molecular profiling panel. Results. In a cohort of 54 never-smokers with lung cancers that were wild-type for known driver mutations, MET exon 14 skipping was the most frequentlyrecurringalteration,occurringin10cancers (19%). Clinical testing at MGH via our next-generation sequencing (NGS) and NGS-rearrangement panels showed an additional 16 casesofMETexon14skipping, for an overall estimated frequency of 5.6%. A clinical case of a patient with MET exon 14 skipping treated with the MET inhibitor crizotinib is also described. Conclusion. METexon14skippingisa targetable gene alteration found in NSCLC. Patients with these alterations may respond well to MET inhibition.

Research Area(s)

  • Lung cancer, MET exon 14 skipping, Targeted therapy

Citation Format(s)

Met exon 14 skipping in non-small cell lung cancer. / Heist, Rebecca S.; Shim, Hyo Sup; Gingipally, Shalini; Mino-Kenudson, Mari; Le, Long; Gainor, Justin F.; Zheng, Zongli; Aryee, Martin; Xia, Junfeng; Jia, Peilin; Jin, Hailing; Zhao, Zhongming; Pao, William; Engelman, Jeffrey A.; Iafrate, A. John.

In: Oncologist, Vol. 21, No. 4, 01.04.2016, p. 481-486.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review