Mesoporous Silica Promoted Deposition of Bioinspired Polydopamine onto Contrast Agent : A Universal Strategy to Achieve Both Biocompatibility and Multiple Scale Molecular Imaging

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

10 Scopus Citations
View graph of relations

Author(s)

  • Yu-Wei Chen
  • Shang-Wei Chou
  • Yu-Jui Tseng
  • Pei-Chun Wu
  • Shin-Kung Wang
  • Yi-Wei Lee
  • Jing-Jong Shyue
  • Jong-Kai Hsiao
  • Tzu-Ming Liu
  • Pi-Tai Chou

Detail(s)

Original languageEnglish
Article number1600415
Journal / PublicationParticle and Particle Systems Characterization
Volume34
Issue number6
Online published27 Mar 2017
Publication statusPublished - Jun 2017
Externally publishedYes

Abstract

Polydopamine (PDA) preserves universal coating and metal-binding ability, and is suitable for application in synthesizing multifunctional agents. Herein, utilizing mesoporous silica assisted deposition to enhance both heterogeneous nucleation and loading amounts of PDA, the magnetic resonance (MR) T1 component (PDA-Fe3+) and MR T2/computed tomography (CT)/multiphoton luminescence (MPL) component (FePt) have been successfully integrated in aqueous solution. This four-in-one (T1, T2, CT, MPL) imaging nanocomposite, FePt@mSiO2 @PDA-polyethylene glycol (PEG), demonstrated its multi-imaging power both in vitro/in vivo. According to our in vitro/in vivo results, FePt@mSiO2@PDA-PEG reveals water-content-dependent property in T1 MR imaging, which suggests the necessity of having dual-modal MR ability in a single particle for the precision diagnosis. Most importantly, this dual (T1,T2)-MRI/CT contrast agent is demonstrated complementary to each other in the in vivo testing. PDA coated mesoporous silica also offers an advantage of delayed degradation that prevents adverse effects caused by silica fragments before excretion. The potential of this nanocomposites in both drug carrier and photothermal agent was further evaluated by using doxorubicin and monitoring solution temperature after irradiating 808 nm continuous-wave, respectively The merits of controlled polymerization, enhanced PDA loading, and biofavorable degradation make this methodology promising to other nanoparticle@mSiO2 for a wide range of bioapplications.

Research Area(s)

  • biocompatibility, mesoporous silica, multiscale imaging, polydopamine

Citation Format(s)

Mesoporous Silica Promoted Deposition of Bioinspired Polydopamine onto Contrast Agent : A Universal Strategy to Achieve Both Biocompatibility and Multiple Scale Molecular Imaging. / Chen, Yu-Wei; Peng, Yung-Kang; Chou, Shang-Wei; Tseng, Yu-Jui; Wu, Pei-Chun; Wang, Shin-Kung; Lee, Yi-Wei; Shyue, Jing-Jong; Hsiao, Jong-Kai; Liu, Tzu-Ming; Chou, Pi-Tai.

In: Particle and Particle Systems Characterization, Vol. 34, No. 6, 1600415, 06.2017.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review