Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review

8 Scopus Citations
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Author(s)

  • Hao-Hao Wang
  • Yi-Xiang J. Wang
  • Ken Cham-Fai Leung
  • Hui Sheng
  • Ge Zhang
  • Simon K. M. Lee
  • Chun-Pong Chak
  • Ling Qin
  • James F. Griffith

Detail(s)

Original languageEnglish
Title of host publication5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008
Pages187-189
Publication statusPublished - 2008

Conference

Title5th International Conference on Information Technology and Applications in Biomedicine (ITAB 2008), in conjunction with
2nd International Symposium & Summer School on Biomedical and Health Engineering (IS3BHE 2008)
LocationSheraton Shenzhen Futian Hotel & Golden Central Hotel
PlaceChina
CityShenzhen
Period30 - 31 May 2008

Abstract

Two types of superparamagnetic iron oxide nanoparticles designed for mesenchymal stem cell labeling and magnetic resonance imaging in vivo tracking were constructed in our laboratories. Both types of nanoparticles have an iron oxide core and a thin layer of silica coating, one of them has additional surface modification with amine. The overall particle size was around 8 nanometers. The in vitro study results demonstrated that, without the application of a transfection agent, both nanoparticles could be incorporated into bone marrow derived mesenchymal stem cells and located in lysosomes. Surface modification with amine significantly increased mesenchymal stem cell labeling efficiency, leading to an increased magnetic resonance imaging detection sensitivity of 2-5 folds. © 2008 IEEE.

Research Area(s)

  • Magnetic resonance imaging, Molecular imaging, Nanoparticles, Stem cell

Citation Format(s)

Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries. / Wang, Hao-Hao; Wang, Yi-Xiang J.; Leung, Ken Cham-Fai et al.
5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008. 2008. p. 187-189 4570593.

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review