Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries

Hao-Hao Wang; Yi-Xiang J. Wang; Ken Cham-Fai Leung; Hui Sheng; Ge Zhang; Simon K. M. Lee; Doris W. T. Au; Chun-Pong Chak; Ling Qin; James F. Griffith

doi:10.1109/ITAB.2008.4570593

Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries

Hao-Hao Wang, Yi-Xiang J. Wang^*, Ken Cham-Fai Leung, Hui Sheng, Ge Zhang, Simon K. M. Lee, Doris W. T. Au, Chun-Pong Chak, Ling Qin, James F. Griffith

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

8 Citations (Scopus)

Abstract

Two types of superparamagnetic iron oxide nanoparticles designed for mesenchymal stem cell labeling and magnetic resonance imaging in vivo tracking were constructed in our laboratories. Both types of nanoparticles have an iron oxide core and a thin layer of silica coating, one of them has additional surface modification with amine. The overall particle size was around 8 nanometers. The in vitro study results demonstrated that, without the application of a transfection agent, both nanoparticles could be incorporated into bone marrow derived mesenchymal stem cells and located in lysosomes. Surface modification with amine significantly increased mesenchymal stem cell labeling efficiency, leading to an increased magnetic resonance imaging detection sensitivity of 2-5 folds. © 2008 IEEE.

Original language	English
Title of host publication	5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008
Pages	187-189
DOIs	https://doi.org/10.1109/ITAB.2008.4570593
Publication status	Published - 2008
Event	5th International Conference on Information Technology and Applications in Biomedicine (ITAB 2008), in conjunction with 2nd International Symposium & Summer School on Biomedical and Health Engineering (IS³BHE 2008) - Sheraton Shenzhen Futian Hotel & Golden Central Hotel, Shenzhen, China Duration: 30 May 2008 → 31 May 2008 https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4570487

Conference

Conference	5th International Conference on Information Technology and Applications in Biomedicine (ITAB 2008), in conjunction with 2nd International Symposium & Summer School on Biomedical and Health Engineering (IS³BHE 2008)
Abbreviated title	ITAB 2008/ IS3BHE 2008
Country/Territory	China
City	Shenzhen
Period	30/05/08 → 31/05/08
Internet address	https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4570487

Research Keywords

Magnetic resonance imaging
Molecular imaging
Nanoparticles
Stem cell

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Wang, H.-H., Wang, Y.-X. J., Leung, K. C.-F., Sheng, H., Zhang, G., Lee, S. K. M., Au, D. W. T., Chak, C.-P., Qin, L., & Griffith, J. F. (2008). Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries. In 5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008 (pp. 187-189). Article 4570593 https://doi.org/10.1109/ITAB.2008.4570593

Wang, Hao-Hao ; Wang, Yi-Xiang J. ; Leung, Ken Cham-Fai et al. / Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries. 5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008. 2008. pp. 187-189

@inproceedings{dc51e8d8b637417ea22907ecc036f46b,

title = "Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries",

abstract = "Two types of superparamagnetic iron oxide nanoparticles designed for mesenchymal stem cell labeling and magnetic resonance imaging in vivo tracking were constructed in our laboratories. Both types of nanoparticles have an iron oxide core and a thin layer of silica coating, one of them has additional surface modification with amine. The overall particle size was around 8 nanometers. The in vitro study results demonstrated that, without the application of a transfection agent, both nanoparticles could be incorporated into bone marrow derived mesenchymal stem cells and located in lysosomes. Surface modification with amine significantly increased mesenchymal stem cell labeling efficiency, leading to an increased magnetic resonance imaging detection sensitivity of 2-5 folds. {\textcopyright} 2008 IEEE.",

keywords = "Magnetic resonance imaging, Molecular imaging, Nanoparticles, Stem cell",

author = "Hao-Hao Wang and Wang, {Yi-Xiang J.} and Leung, {Ken Cham-Fai} and Hui Sheng and Ge Zhang and Lee, {Simon K. M.} and Au, {Doris W. T.} and Chun-Pong Chak and Ling Qin and Griffith, {James F.}",

year = "2008",

doi = "10.1109/ITAB.2008.4570593",

language = "English",

isbn = "9781424422555",

pages = "187--189",

booktitle = "5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008",

note = "5th International Conference on Information Technology and Applications in Biomedicine (ITAB 2008), in conjunction with 2nd International Symposium & Summer School on Biomedical and Health Engineering (IS3BHE 2008), ITAB 2008/ IS3BHE 2008 ; Conference date: 30-05-2008 Through 31-05-2008",

url = "https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4570487",

}

Wang, H-H, Wang, Y-XJ, Leung, KC-F, Sheng, H, Zhang, G, Lee, SKM, Au, DWT, Chak, C-P, Qin, L & Griffith, JF 2008, Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries. in 5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008., 4570593, pp. 187-189, 5th International Conference on Information Technology and Applications in Biomedicine (ITAB 2008), in conjunction with
2nd International Symposium & Summer School on Biomedical and Health Engineering (IS³BHE 2008), Shenzhen, China, 30/05/08. https://doi.org/10.1109/ITAB.2008.4570593

Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries. / Wang, Hao-Hao; Wang, Yi-Xiang J.; Leung, Ken Cham-Fai et al.
5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008. 2008. p. 187-189 4570593.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries

AU - Wang, Hao-Hao

AU - Wang, Yi-Xiang J.

AU - Leung, Ken Cham-Fai

AU - Sheng, Hui

AU - Zhang, Ge

AU - Lee, Simon K. M.

AU - Au, Doris W. T.

AU - Chak, Chun-Pong

AU - Qin, Ling

AU - Griffith, James F.

PY - 2008

Y1 - 2008

N2 - Two types of superparamagnetic iron oxide nanoparticles designed for mesenchymal stem cell labeling and magnetic resonance imaging in vivo tracking were constructed in our laboratories. Both types of nanoparticles have an iron oxide core and a thin layer of silica coating, one of them has additional surface modification with amine. The overall particle size was around 8 nanometers. The in vitro study results demonstrated that, without the application of a transfection agent, both nanoparticles could be incorporated into bone marrow derived mesenchymal stem cells and located in lysosomes. Surface modification with amine significantly increased mesenchymal stem cell labeling efficiency, leading to an increased magnetic resonance imaging detection sensitivity of 2-5 folds. © 2008 IEEE.

AB - Two types of superparamagnetic iron oxide nanoparticles designed for mesenchymal stem cell labeling and magnetic resonance imaging in vivo tracking were constructed in our laboratories. Both types of nanoparticles have an iron oxide core and a thin layer of silica coating, one of them has additional surface modification with amine. The overall particle size was around 8 nanometers. The in vitro study results demonstrated that, without the application of a transfection agent, both nanoparticles could be incorporated into bone marrow derived mesenchymal stem cells and located in lysosomes. Surface modification with amine significantly increased mesenchymal stem cell labeling efficiency, leading to an increased magnetic resonance imaging detection sensitivity of 2-5 folds. © 2008 IEEE.

KW - Magnetic resonance imaging

KW - Molecular imaging

KW - Nanoparticles

KW - Stem cell

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U2 - 10.1109/ITAB.2008.4570593

DO - 10.1109/ITAB.2008.4570593

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781424422555

SP - 187

EP - 189

BT - 5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008

T2 - 5th International Conference on Information Technology and Applications in Biomedicine (ITAB 2008), in conjunction with 2nd International Symposium & Summer School on Biomedical and Health Engineering (IS3BHE 2008)

Y2 - 30 May 2008 through 31 May 2008

ER -

Wang HH, Wang YXJ, Leung KCF, Sheng H, Zhang G, Lee SKM et al. Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries. In 5th Int. Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd Int. Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008. 2008. p. 187-189. 4570593 doi: 10.1109/ITAB.2008.4570593

Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries

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