Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

1 Scopus Citations
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Author(s)

  • Huan Chen
  • Shengliang Li
  • Min Wu
  • Kenry
  • Bin Liu

Detail(s)

Original languageEnglish
Pages (from-to)632-636
Journal / PublicationAngewandte Chemie (International Edition)
Volume59
Issue number2
Online published26 Nov 2019
Publication statusPublished - 7 Jan 2020

Abstract

Traditional photosensitizers (PSs) show reduced singlet oxygen (1O2) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non-targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes and small effective working radii. Herein, a water-dispersible membrane anchor (TBD-anchor) PS with aggregation-induced emission is designed and synthesized to generate 1O2 on the bacterial membrane. TBD-anchor showed efficient antibacterial performance towards both Gram-negative (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). Over 99.8 % killing efficiency was obtained for methicillin-resistant S. aureus (MRSA) when they were exposed to 0.8 μm of TBD-anchor at a low white light dose (25 mW cm−2) for 10 minutes. TBD-anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug-resistant bacteria.

Research Area(s)

  • aggregation-induced emission, antibacterial activity, fluorescence imaging, membrane anchor, photodynamic therapy

Citation Format(s)

Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria. / Chen, Huan; Li, Shengliang; Wu, Min; Kenry, ; Huang, Zhongming; Lee, Chun-Sing; Liu, Bin.

In: Angewandte Chemie (International Edition), Vol. 59, No. 2, 07.01.2020, p. 632-636.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal