Mediated Drug Release from Nanovehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease

Zhibin Li; Guanghong Luo; Wei-Ping Hu; Jian-Lan Hua; Shengyong Geng; Paul K. Chu; Jing Zhang; Huaiyu Wang; Xue-Feng Yu

doi:10.1002/ange.202008379

Mediated Drug Release from Nanovehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease

Zhibin Li (Co-first Author), Guanghong Luo (Co-first Author), Wei-Ping Hu (Co-first Author), Jian-Lan Hua, Shengyong Geng, Paul K. Chu, Jing Zhang^*, Huaiyu Wang^*, Xue-Feng Yu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Abstract

Chronic obstructive pulmonary disease (COPD) is an intractable disease involving a sticky mucus layer and nanoagents with mucus-penetrating capability offer a new way to deliver drugs. However, drug release from nanovehicles requires optimization to enhance the therapeutic effects of COPD therapy. Herein, black phosphorus quantum dots (BPQDs) are combined with PEGylated chitosan nanospheres containing the antibiotic amikacin (termed PEG@CS/BPQDs-AM NPs). As a drug-delivery system, the hydrophilicity of PEG and positive charge of CS facilitate the penetration of nanovehicles through the mucus layer. The nanovehicles then adhere to the mucous membrane. Furthermore, the BPQDs degrade rapidly into nontoxic PO₄³⁻ and acidic H⁺, thereby promoting the dissociation of PEGylated CS nanospheres, accelerating the release of AM, decreasing the vitality of biofilms for ease of eradication. Our results reveal that drug delivery mediated by BPQDs is a feasible and desirable strategy for precision medicine and promising for the clinical therapy of COPD. © 2020 Wiley-VCH GmbH

Original language	English
Pages (from-to)	20749–20757
Journal	Angewandte Chemie
Volume	132
Issue number	46
Online published	15 Jul 2020
DOIs	https://doi.org/10.1002/ange.202008379
Publication status	Published - 9 Nov 2020

Research Keywords

2D materials
black phosphorus
chronic obstructive pulmonary disease
nanoparticles
quantum dots

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title = "Mediated Drug Release from Nanovehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease",

abstract = "Chronic obstructive pulmonary disease (COPD) is an intractable disease involving a sticky mucus layer and nanoagents with mucus-penetrating capability offer a new way to deliver drugs. However, drug release from nanovehicles requires optimization to enhance the therapeutic effects of COPD therapy. Herein, black phosphorus quantum dots (BPQDs) are combined with PEGylated chitosan nanospheres containing the antibiotic amikacin (termed PEG@CS/BPQDs-AM NPs). As a drug-delivery system, the hydrophilicity of PEG and positive charge of CS facilitate the penetration of nanovehicles through the mucus layer. The nanovehicles then adhere to the mucous membrane. Furthermore, the BPQDs degrade rapidly into nontoxic PO43− and acidic H+, thereby promoting the dissociation of PEGylated CS nanospheres, accelerating the release of AM, decreasing the vitality of biofilms for ease of eradication. Our results reveal that drug delivery mediated by BPQDs is a feasible and desirable strategy for precision medicine and promising for the clinical therapy of COPD. {\textcopyright} 2020 Wiley-VCH GmbH",

keywords = "2D materials, black phosphorus, chronic obstructive pulmonary disease, nanoparticles, quantum dots, 2D materials, black phosphorus, chronic obstructive pulmonary disease, nanoparticles, quantum dots, 2D materials, black phosphorus, chronic obstructive pulmonary disease, nanoparticles, quantum dots",

author = "Zhibin Li and Guanghong Luo and Wei-Ping Hu and Jian-Lan Hua and Shengyong Geng and Chu, {Paul K.} and Jing Zhang and Huaiyu Wang and Xue-Feng Yu",

year = "2020",

month = nov,

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doi = "10.1002/ange.202008379",

language = "English",

volume = "132",

pages = "20749–20757",

journal = "Angewandte Chemie",

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Mediated Drug Release from Nanovehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease. / Li, Zhibin (Co-first Author); Luo, Guanghong (Co-first Author); Hu, Wei-Ping (Co-first Author) et al.
In: Angewandte Chemie, Vol. 132, No. 46, 09.11.2020, p. 20749–20757.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Mediated Drug Release from Nanovehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease

AU - Li, Zhibin

AU - Luo, Guanghong

AU - Hu, Wei-Ping

AU - Hua, Jian-Lan

AU - Geng, Shengyong

AU - Chu, Paul K.

AU - Zhang, Jing

AU - Wang, Huaiyu

AU - Yu, Xue-Feng

PY - 2020/11/9

Y1 - 2020/11/9

N2 - Chronic obstructive pulmonary disease (COPD) is an intractable disease involving a sticky mucus layer and nanoagents with mucus-penetrating capability offer a new way to deliver drugs. However, drug release from nanovehicles requires optimization to enhance the therapeutic effects of COPD therapy. Herein, black phosphorus quantum dots (BPQDs) are combined with PEGylated chitosan nanospheres containing the antibiotic amikacin (termed PEG@CS/BPQDs-AM NPs). As a drug-delivery system, the hydrophilicity of PEG and positive charge of CS facilitate the penetration of nanovehicles through the mucus layer. The nanovehicles then adhere to the mucous membrane. Furthermore, the BPQDs degrade rapidly into nontoxic PO43− and acidic H+, thereby promoting the dissociation of PEGylated CS nanospheres, accelerating the release of AM, decreasing the vitality of biofilms for ease of eradication. Our results reveal that drug delivery mediated by BPQDs is a feasible and desirable strategy for precision medicine and promising for the clinical therapy of COPD. © 2020 Wiley-VCH GmbH

AB - Chronic obstructive pulmonary disease (COPD) is an intractable disease involving a sticky mucus layer and nanoagents with mucus-penetrating capability offer a new way to deliver drugs. However, drug release from nanovehicles requires optimization to enhance the therapeutic effects of COPD therapy. Herein, black phosphorus quantum dots (BPQDs) are combined with PEGylated chitosan nanospheres containing the antibiotic amikacin (termed PEG@CS/BPQDs-AM NPs). As a drug-delivery system, the hydrophilicity of PEG and positive charge of CS facilitate the penetration of nanovehicles through the mucus layer. The nanovehicles then adhere to the mucous membrane. Furthermore, the BPQDs degrade rapidly into nontoxic PO43− and acidic H+, thereby promoting the dissociation of PEGylated CS nanospheres, accelerating the release of AM, decreasing the vitality of biofilms for ease of eradication. Our results reveal that drug delivery mediated by BPQDs is a feasible and desirable strategy for precision medicine and promising for the clinical therapy of COPD. © 2020 Wiley-VCH GmbH

KW - 2D materials

KW - black phosphorus

KW - chronic obstructive pulmonary disease

KW - nanoparticles

KW - quantum dots

KW - 2D materials

KW - black phosphorus

KW - chronic obstructive pulmonary disease

KW - nanoparticles

KW - quantum dots

KW - 2D materials

KW - black phosphorus

KW - chronic obstructive pulmonary disease

KW - nanoparticles

KW - quantum dots

U2 - 10.1002/ange.202008379

DO - 10.1002/ange.202008379

M3 - RGC 21 - Publication in refereed journal

SN - 0044-8249

VL - 132

SP - 20749

EP - 20757

JO - Angewandte Chemie

JF - Angewandte Chemie

IS - 46

ER -

Mediated Drug Release from Nanovehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease

Abstract

Research Keywords

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GRF: Nanostructured Ti-Based and Polymeric Orthopedic Implant Materials with Tailored Mechanobiocidal and Osteogenic Properties

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