Mechanisms underlying toxicity induced by CdTe quantum dots determined in an invertebrate model organism

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Alfredo Ambrosone
  • Lucia Mattera
  • Valentina Marchesano
  • Alessandra Quarta
  • Andrei S. Susha
  • Angela Tino
  • Claudia Tortiglione

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)1991-2000
Journal / PublicationBiomaterials
Volume33
Issue number7
Publication statusPublished - Mar 2012

Abstract

A systematic and thorough quantitative analysis of the invivo effects of inorganic nanoparticles is extremely important for the design of functional nanomaterials for diagnostic and therapeutic applications, better understanding of their non-specificity toward tissues and cell types, and for assessments of their toxicity. This study was undertaken to examine the impact of CdTe quantum dots (QDs) on an invertebrate freshwater model organism, Hydra vulgaris, for assessment of long term toxicity effects. The continuous exposure of living polyps to sub-lethal doses of QDs caused time and dose dependent morphological damages more severe than Cd 2+ ions at the same concentrations, impaired both reproductive and regenerative capability, activated biochemical and molecular responses. Of remarkable interest, low QD doses, apparently not effective, caused early changes in the expression of general stress responsive and apoptotic genes. The occurrence of subtle genetic variations, in the absence of morphological damages, indicates the importance of genotoxicity studies for nanoparticle risk assessment. The versatility in morphological, cellular, biochemical and molecular responses renders Hydra a perfect model system for high-throughput screening of toxicological and ecotoxicological impact of nanomaterials on human and environmental health. © 2011 Elsevier Ltd.

Research Area(s)

  • Animal model, CdTe quantum dots, Cytotoxicity, Genotoxicity, Invivo test

Citation Format(s)

Mechanisms underlying toxicity induced by CdTe quantum dots determined in an invertebrate model organism. / Ambrosone, Alfredo; Mattera, Lucia; Marchesano, Valentina; Quarta, Alessandra; Susha, Andrei S.; Tino, Angela; Rogach, Andrey L.; Tortiglione, Claudia.

In: Biomaterials, Vol. 33, No. 7, 03.2012, p. 1991-2000.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal