Mechanism of cell repellence on quasi-aligned nanowire arrays on Ti alloy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Lingzhou Zhao
  • Liangsheng Hu
  • Kaifu Huo
  • Yumei Zhang
  • Zhifen Wu

Detail(s)

Original languageEnglish
Pages (from-to)8341-8349
Journal / PublicationBiomaterials
Volume31
Issue number32
Publication statusPublished - Nov 2010

Abstract

Cell-repelling structures are often required in biosensors, bioelectronics, and drug delivery systems, but the search for satisfactory cell-repelling structures with good biocompatibility and long-term stability is challenging. In this work, two types of quasi-aligned nanowire arrays (QANWA) with different surface chemistry but similar surface topography, namely titanium carbide-carbon core-shell (TiC/C) and titania (TiO2), are fabricated on Ti6Al4V. Both QANWAs inhibit cell adhesion consequently leading to cell apoptosis possibly due to disruption in the adhesion assembly. Other cell functions such as proliferation and differentiation as monitored by extracellular matrix secretion and mineralization are also substantially depressed. The cell-repelling property is related to the nanostructure but independent of the surface chemistry and surface wettability. It is also not related to protein adsorption which is in fact slightly enhanced on the nanowire arrays. The QANWAs can be modified to have a larger loading capacity thereby enhancing the controlled release kinetics in drug delivery applications and to resist protein adsorption resulting in better biosensor performance. This concept which can be readily extended to other types of QANWAs and biomaterials has broad clinical potential. © 2010 Elsevier Ltd.

Research Area(s)

  • Apoptosis, Cell adhesion, Nanowire arrays, Surface chemistry, Wettability

Citation Format(s)

Mechanism of cell repellence on quasi-aligned nanowire arrays on Ti alloy. / Zhao, Lingzhou; Hu, Liangsheng; Huo, Kaifu; Zhang, Yumei; Wu, Zhifen; Chu, Paul K.

In: Biomaterials, Vol. 31, No. 32, 11.2010, p. 8341-8349.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal