Abstract
Flexible polymer-based neural probes are promising tools to interfaces with brain tissue since the low stiffness and thin geometry of these probes make them compliant to soft tissue in a manner that allows for reducing the inflammation responses. However, the same properties make flexible probes susceptible to bending and buckling during insertion, which make the implantation impossible. This paper provides a brief review of recent advances in mechanics strategies to assist the insertion of flexible probes. The basic concept of each strategy is summarized with advantages and disadvantages briefly discussed. These results provide a guide for reliable implantations of flexible neural probes for chronic brain electrophysiological recording and clinical treatment of neurological disorders. Copyright © 2020 by ASME.
| Original language | English |
|---|---|
| Article number | 010801 |
| Number of pages | 12 |
| Journal | Journal of Applied Mechanics, Transactions ASME |
| Volume | 88 |
| Issue number | 1 |
| Online published | 28 Sept 2020 |
| DOIs | |
| Publication status | Published - Jan 2021 |
| Externally published | Yes |
Funding
J.S. acknowledges the supports from the National Natural Science Foundation of China (Grant Nos. 11872331 and 11622221) and the Fundamental Research Funds for the Central Universities.
Research Keywords
- Flexible neural probe
- Implantation
- Insertion strategy
- Mechanical properties of materials
- Structures
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