Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Qian Feng
  • Kongchang Wei
  • Sien Lin
  • Yuxin Sun
  • Gang Li
  • Liming Bian

Detail(s)

Original languageEnglish
Pages (from-to)217-228
Journal / PublicationBiomaterials
Volume101
Online published2 Jun 2016
Publication statusPublished - Sep 2016

Abstract

Although considered promising materials for assisting organ regeneration, few hydrogels meet the stringent requirements of clinical translation on the preparation, application, mechanical property, bioadhesion, and biocompatibility of the hydrogels. Herein, we describe a facile supramolecular approach for preparing gelatin hydrogels with a wide array of desirable properties. Briefly, we first prepare a supramolecular gelatin macromer via the efficient host-guest complexation between the aromatic residues of gelatin and free diffusing photo-crosslinkable acrylated β-cyclodextrin (β-CD) monomers. The subsequent crosslinking of the macromers produces highly resilient supramolecular gelatin hydrogels that are solely crosslinked by the weak host-guest interactions between the gelatinous aromatic residues and β-cyclodextrin (β-CD). The obtained hydrogels are capable of sustaining excessive compressive and tensile strain, and they are capable of quick self healing after mechanical disruption. These hydrogels can be injected in the gelation state through surgical needles and re-molded to the targeted geometries while protecting the encapsulated cells. Moreover, the weak host-guest crosslinking likely facilitate the infiltration and migration of cells into the hydrogels. The excess β-CDs in the hydrogels enable the hydrogel-tissue adhesion and enhance the loading and sustained delivery of hydrophobic drugs. The cell and animal studies show that such hydrogels support cell recruitment, differentiation, and bone regeneration, making them promising carrier biomaterials of therapeutic cells and drugs via minimally invasive procedures.

Research Area(s)

  • Biomaterial carrier, Drug delivery, Host-guest complexation, Supramolecular hydrogel, Tissue regeneration

Citation Format(s)

Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration. / Feng, Qian; Wei, Kongchang; Lin, Sien; Xu, Zhen; Sun, Yuxin; Shi, Peng; Li, Gang; Bian, Liming.

In: Biomaterials, Vol. 101, 09.2016, p. 217-228.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal