TY - JOUR
T1 - Mechanical properties, biodegradation behavior and biocompatibility of novel Zn-based alloy membranes prepared by powder metallurgy for guided bone regeneration
AU - Chu, Xin
AU - Dai, Yilong
AU - Fu, Zhendi
AU - Wang, Jun
AU - Song, Jueming
AU - Dong, Zhibin
AU - Tang, Zijun
AU - Yan, Yang
AU - Yu, Kun
PY - 2025/1
Y1 - 2025/1
N2 - Pure zinc is inappropriate for guided bone regeneration (GBR) membranes due to its low mechanical properties. Herein, Zn-based alloy GBR membranes were prepared by powder metallurgy method to yield Zn-0.5Fe-0.05Mg and Zn-0.5Mg-0.05Fe alloy GBR membranes. The testing of mechanical properties showed tensile strengths of Pure Zn and Zn-0.5Fe-0.05Mg and Zn-0.5Mg-0.05Fe alloy GBR membranes reaching 88.9 MPa 331.2 MPa and 352.2 MPa, along with elongations of 9.8 % and 25.8 % and 20.2 %, respectively. Therefore, the addition of Fe and Mg greatly increased the strength of the zinc alloy. The corrosion potentials of Zn-0.5Fe-0.05Mg and Zn-0.5Mg-0.05Fe alloy GBR membranes were determined as −1.296 V and −1.309 V, respectively. Their corrosion current densities reached 12.05 μA/cm2 and 13.65 μA/cm2 with corrosion rates of 0.180 mm/year and 0.210 mm/year, respectively. Importantly, the extracts of both Zn-based alloy GBR membranes illustrated good cytocompatibility with a cytotoxicity grade of 0–1. Both Zn-based alloy GBR membranes exhibited good osteogenic ability with quantitative bone volume/tissue volume (BV/TV) ratios for new bone formation reaching 30.3 ± 1.4 % and 65.5 ± 1.8 % after 12 weeks, suggesting good new bone growth ability. Overall, the proposed Zn-0.5Fe-0.05Mg and Zn-0.5Mg-0.05Fe alloy GBR membranes have the potential for applications as biodegradable materials for clinical research. © 2024 Elsevier Ltd
AB - Pure zinc is inappropriate for guided bone regeneration (GBR) membranes due to its low mechanical properties. Herein, Zn-based alloy GBR membranes were prepared by powder metallurgy method to yield Zn-0.5Fe-0.05Mg and Zn-0.5Mg-0.05Fe alloy GBR membranes. The testing of mechanical properties showed tensile strengths of Pure Zn and Zn-0.5Fe-0.05Mg and Zn-0.5Mg-0.05Fe alloy GBR membranes reaching 88.9 MPa 331.2 MPa and 352.2 MPa, along with elongations of 9.8 % and 25.8 % and 20.2 %, respectively. Therefore, the addition of Fe and Mg greatly increased the strength of the zinc alloy. The corrosion potentials of Zn-0.5Fe-0.05Mg and Zn-0.5Mg-0.05Fe alloy GBR membranes were determined as −1.296 V and −1.309 V, respectively. Their corrosion current densities reached 12.05 μA/cm2 and 13.65 μA/cm2 with corrosion rates of 0.180 mm/year and 0.210 mm/year, respectively. Importantly, the extracts of both Zn-based alloy GBR membranes illustrated good cytocompatibility with a cytotoxicity grade of 0–1. Both Zn-based alloy GBR membranes exhibited good osteogenic ability with quantitative bone volume/tissue volume (BV/TV) ratios for new bone formation reaching 30.3 ± 1.4 % and 65.5 ± 1.8 % after 12 weeks, suggesting good new bone growth ability. Overall, the proposed Zn-0.5Fe-0.05Mg and Zn-0.5Mg-0.05Fe alloy GBR membranes have the potential for applications as biodegradable materials for clinical research. © 2024 Elsevier Ltd
KW - Biocompatibility
KW - Guided bone regeneration membranes
KW - Osteogenic properties
KW - Powder metallurgy
KW - Zn-based alloy
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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85212576416&origin=recordpage
U2 - 10.1016/j.mtcomm.2024.111367
DO - 10.1016/j.mtcomm.2024.111367
M3 - RGC 21 - Publication in refereed journal
SN - 2352-4928
VL - 42
JO - Materials Today Communications
JF - Materials Today Communications
M1 - 111367
ER -