Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review

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Author(s)

Detail(s)

Original languageEnglish
Title of host publication2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008
Pages499-501
Publication statusPublished - 2008
Externally publishedYes

Publication series

Name2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008

Conference

Title2008 ASME 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008
PlaceHong Kong
CityKowloon
Period3 - 5 June 2008

Abstract

A microfluidic biochip has been fabricated to retain a single cell (e.g. a cancerous cell) within a U-shaped cell retention structure for real-time monitoring of cellular changes over long periods of time (hours). Experiments illustrate the cell heterogeneity in drug responses, and demonstrate the significance of the microchip platform for cancer diagnosis. This microdevice provides a clinical diagnostic platform to evaluate multi-drug-resistance in cancer patients. This device may increase the effectiveness of current chemotherapeutic strategies by evaluating an individual's cellular response to these agents. Copyright © 2008 by ASME.

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis. / Li, Paul; Chew, Derek.

2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008. 2008. p. 499-501 (2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008).

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review