Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis

Paul Li; Derek Chew

doi:10.1115/MicroNano2008-70164

Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis

Paul Li
, Derek Chew

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

1 Citation (Scopus)

Abstract

A microfluidic biochip has been fabricated to retain a single cell (e.g. a cancerous cell) within a U-shaped cell retention structure for real-time monitoring of cellular changes over long periods of time (hours). Experiments illustrate the cell heterogeneity in drug responses, and demonstrate the significance of the microchip platform for cancer diagnosis. This microdevice provides a clinical diagnostic platform to evaluate multi-drug-resistance in cancer patients. This device may increase the effectiveness of current chemotherapeutic strategies by evaluating an individual's cellular response to these agents. Copyright © 2008 by ASME.

Original language	English
Title of host publication	2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008
Pages	499-501
DOIs	https://doi.org/10.1115/MicroNano2008-70164
Publication status	Published - 2008
Externally published	Yes
Event	2008 ASME 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008 - Kowloon, Hong Kong, China Duration: 3 Jun 2008 → 5 Jun 2008

Publication series

Name	2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008

Conference

Conference	2008 ASME 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008
Place	Hong Kong, China
City	Kowloon
Period	3/06/08 → 5/06/08

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Li, P., & Chew, D. (2008). Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis. In 2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008 (pp. 499-501). (2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008). https://doi.org/10.1115/MicroNano2008-70164

Li, Paul ; Chew, Derek. / Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis. 2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008. 2008. pp. 499-501 (2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008).

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abstract = "A microfluidic biochip has been fabricated to retain a single cell (e.g. a cancerous cell) within a U-shaped cell retention structure for real-time monitoring of cellular changes over long periods of time (hours). Experiments illustrate the cell heterogeneity in drug responses, and demonstrate the significance of the microchip platform for cancer diagnosis. This microdevice provides a clinical diagnostic platform to evaluate multi-drug-resistance in cancer patients. This device may increase the effectiveness of current chemotherapeutic strategies by evaluating an individual's cellular response to these agents. Copyright {\textcopyright} 2008 by ASME.",

author = "Paul Li and Derek Chew",

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Li, P & Chew, D 2008, Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis. in 2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008. 2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008, pp. 499-501, 2008 ASME 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008, Kowloon, Hong Kong, China, 3/06/08. https://doi.org/10.1115/MicroNano2008-70164

Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis. / Li, Paul; Chew, Derek.
2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008. 2008. p. 499-501 (2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

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AB - A microfluidic biochip has been fabricated to retain a single cell (e.g. a cancerous cell) within a U-shaped cell retention structure for real-time monitoring of cellular changes over long periods of time (hours). Experiments illustrate the cell heterogeneity in drug responses, and demonstrate the significance of the microchip platform for cancer diagnosis. This microdevice provides a clinical diagnostic platform to evaluate multi-drug-resistance in cancer patients. This device may increase the effectiveness of current chemotherapeutic strategies by evaluating an individual's cellular response to these agents. Copyright © 2008 by ASME.

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T3 - 2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008

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Li P, Chew D. Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis. In 2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008. 2008. p. 499-501. (2008 Proceedings of the ASME - 2nd International Conference on Integration and Commercialization of Micro and Nanosystems, MicroNano 2008). doi: 10.1115/MicroNano2008-70164

Measurement of intracellular drug concentration in a single cancer cell isolated in a microfabricated biochip for cancer diagnosis

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

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