Abstract
The budding yeast Saccharomyces cerevisiae is a powerful model system for studying the cell polarity establishment. The cell polarization process is regulated by signaling molecules, which are initially distributed in the cytoplasm and then recruited to a proper location on the cell membrane in response to spatial cues or spontaneously. Polarization of these signaling molecules involves complex regulation, so the mathematical models become a useful tool to investigate the mechanism behind the process. In this review, we discuss how mathematical modeling has shed light on different regulations in the cell polarization. We also propose future applications for the mathematical modeling of cell polarization and morphogenesis. © Shanghai University 2023.
| Original language | English |
|---|---|
| Pages (from-to) | 218-235 |
| Journal | Communications on Applied Mathematics and Computation |
| Volume | 6 |
| Issue number | 1 |
| Online published | 13 Feb 2023 |
| DOIs | |
| Publication status | Published - Mar 2024 |
Research Keywords
- Budding yeast
- Cdc42
- Mathematical models
- Morphogenesis
- Septin
Publisher's Copyright Statement
- COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s42967-022-00240-y.