Mass vaccination, immunity and coverage: Modelling population protection against foot-and-mouth disease in Turkish cattle

T. J D Knight-Jones; S. Gubbins; A. N. Bulut; K. D C Stärk; D. U. Pfeiffer; K. J. Sumption; D. J. Paton

doi:10.1038/srep22121

Mass vaccination, immunity and coverage: Modelling population protection against foot-and-mouth disease in Turkish cattle

T. J D Knight-Jones^*, S. Gubbins, A. N. Bulut, K. D C Stärk, D. U. Pfeiffer, K. J. Sumption, D. J. Paton

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last round of vaccination almost half the cattle aged 1 vaccine dose in their life with the last dose given ≤6 months ago. Five months after the last round of vaccination two-thirds of cattle would have low antibody titres (

Original language	English
Article number	22121
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep22121
Publication status	Published - 26 Feb 2016
Externally published	Yes

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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abstract = "Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last round of vaccination almost half the cattle aged 1 vaccine dose in their life with the last dose given ≤6 months ago. Five months after the last round of vaccination two-thirds of cattle would have low antibody titres (",

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AU - Gubbins, S.

AU - Bulut, A. N.

AU - Stärk, K. D C

AU - Pfeiffer, D. U.

AU - Sumption, K. J.

AU - Paton, D. J.

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N2 - Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last round of vaccination almost half the cattle aged 1 vaccine dose in their life with the last dose given ≤6 months ago. Five months after the last round of vaccination two-thirds of cattle would have low antibody titres (

AB - Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last round of vaccination almost half the cattle aged 1 vaccine dose in their life with the last dose given ≤6 months ago. Five months after the last round of vaccination two-thirds of cattle would have low antibody titres (

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Mass vaccination, immunity and coverage: Modelling population protection against foot-and-mouth disease in Turkish cattle

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