Mapping Drug-Induced Neuropathy through In-Situ Motor Protein Tracking and Machine Learning

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Zhigao Yi
  • Huxin Gao
  • Xin-Yi Yeo
  • Suet Yen Chong
  • Yujie Mao
  • Baiwen Luo
  • Chao Shen
  • Sanyang Han
  • Jiong-Wei Wang
  • Sangyong Jung
  • Hongliang Ren
  • Xiaogang Liu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)14907–14915
Journal / PublicationJournal of the American Chemical Society
Volume143
Issue number36
Online published1 Sep 2021
Publication statusPublished - 15 Sep 2021

Abstract

Chemotherapy can induce toxicity in the central and peripheral nervous systems and result in chronic adverse reactions that impede continuous treatment and reduce patient quality of life. There is a current lack of research to predict, identify, and offset drug-induced neurotoxicity. Rapid and accurate assessment of potential neuropathy is crucial for cost-effective diagnosis and treatment. Here we report dynamic near-infrared upconversion imaging that allows intraneuronal transport to be traced in real time with millisecond resolution, but without photobleaching or blinking. Drug-induced neurotoxicity can be screened prior to phenotyping, on the basis of subtle abnormalities of kinetic characteristics in intraneuronal transport. Moreover, we demonstrate that combining the upconverting nanoplatform with machine learning offers a powerful tool for mapping chemotherapy-induced peripheral neuropathy and assessing drug-induced neurotoxicity.

Citation Format(s)

Mapping Drug-Induced Neuropathy through In-Situ Motor Protein Tracking and Machine Learning. / Yi, Zhigao; Gao, Huxin; Ji, Xianglin; Yeo, Xin-Yi; Chong, Suet Yen; Mao, Yujie; Luo, Baiwen; Shen, Chao; Han, Sanyang; Wang, Jiong-Wei; Jung, Sangyong; Shi, Peng; Ren, Hongliang; Liu, Xiaogang.

In: Journal of the American Chemical Society, Vol. 143, No. 36, 15.09.2021, p. 14907–14915.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review