Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation

Qingsong Mei; Akshaya Bansal; Muthu Kumara Gnanasammandhan Jayakumar; Zhiming Zhang; Jing Zhang; Hua Huang; Dejie Yu; Chrishan J. A. Ramachandra; Derek J. Hausenloy; Tuck Wah Soong; Yong Zhang

doi:10.1038/s41467-019-12374-4

Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation

Qingsong Mei
, Akshaya Bansal
, Muthu Kumara Gnanasammandhan Jayakumar
, Zhiming Zhang
, Jing Zhang
, Hua Huang
, Dejie Yu
, Chrishan J. A. Ramachandra
, Derek J. Hausenloy
, Tuck Wah Soong
, Yong Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

105 Citations (Scopus)

31 Downloads (CityUHK Scholars)

Abstract

Reliance on low tissue penetrating UV or visible light limits clinical applicability of phototherapy, necessitating use of deep tissue penetrating near-infrared (NIR) to visible light transducers like upconversion nanoparticles (UCNPs). While typical UCNPs produce multiple simultaneous emissions for unidirectional control of biological processes, programmable control requires orthogonal non-overlapping light emissions. These can be obtained through doping nanocrystals with multiple activator ions. However, this requires tedious synthesis and produces complicated multi-shell nanoparticles with a lack of control over emission profiles due to activator crosstalk. Herein, we explore cross-relaxation (CR), a non-radiative recombination pathway typically perceived as deleterious, to manipulate energy migration within the same lanthanide activator ion (Er³⁺) towards orthogonal red and green emissions, simply by adjusting excitation wavelength from 980 to 808 nm. These UCNPs allow programmable activation of two synergistic light-gated ion channels VChR1 and Jaws in the same cell to manipulate membrane polarization, demonstrated here for cardiac pacing. © 2019, The Author(s).

Original language	English
Article number	4416
Journal	Nature Communications
Volume	10
Online published	27 Sept 2019
DOIs	https://doi.org/10.1038/s41467-019-12374-4
Publication status	Published - 1 Dec 2019
Externally published	Yes

Funding

This work was mainly supported by grants from Singapore Ministry of Education (MOE2016-T3-1-004), National Medical Research Council (NMRC/OFIRG/17nov066) and the National Natural Science Foundation of China (21675038, 31671011). D.J.H. was supported by the British Heart Foundation (CS/14/3/31002), the National Institute for Health Research University College London Hospitals Biomedical Research Centre, Duke-National University Singapore Medical School, Singapore Ministry of Health’s National Medical Research Council under its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/CGAug16C006), and the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2016-T2-2-021). C.J.A.R. was supported by the Singapore Ministry of Health’s National Medical Research Council under its Open Fund-Young Individual Research Grant (OF-YIRG) – [NMRC/OFYIRG/0073/2018] and through the National Health Innovation Centre Singapore under its Innovation to Develop Grant (NHIC-I2S-1811007).

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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Mei, Q., Bansal, A., Jayakumar, M. K. G., Zhang, Z., Zhang, J., Huang, H., Yu, D., Ramachandra, C. J. A., Hausenloy, D. J., Soong, T. W., & Zhang, Y. (2019). Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation. Nature Communications, 10, Article 4416. https://doi.org/10.1038/s41467-019-12374-4

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abstract = "Reliance on low tissue penetrating UV or visible light limits clinical applicability of phototherapy, necessitating use of deep tissue penetrating near-infrared (NIR) to visible light transducers like upconversion nanoparticles (UCNPs). While typical UCNPs produce multiple simultaneous emissions for unidirectional control of biological processes, programmable control requires orthogonal non-overlapping light emissions. These can be obtained through doping nanocrystals with multiple activator ions. However, this requires tedious synthesis and produces complicated multi-shell nanoparticles with a lack of control over emission profiles due to activator crosstalk. Herein, we explore cross-relaxation (CR), a non-radiative recombination pathway typically perceived as deleterious, to manipulate energy migration within the same lanthanide activator ion (Er3+) towards orthogonal red and green emissions, simply by adjusting excitation wavelength from 980 to 808 nm. These UCNPs allow programmable activation of two synergistic light-gated ion channels VChR1 and Jaws in the same cell to manipulate membrane polarization, demonstrated here for cardiac pacing. {\textcopyright} 2019, The Author(s).",

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Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation. / Mei, Qingsong; Bansal, Akshaya; Jayakumar, Muthu Kumara Gnanasammandhan et al.
In: Nature Communications, Vol. 10, 4416, 01.12.2019.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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AU - Zhang, Zhiming

AU - Zhang, Jing

AU - Huang, Hua

AU - Yu, Dejie

AU - Ramachandra, Chrishan J. A.

AU - Hausenloy, Derek J.

AU - Soong, Tuck Wah

AU - Zhang, Yong

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Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation

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