Magnetization transfer contrast (MTC) suppressed relayed nuclear Overhauser enhancement (rNOE) imaging at 3 T

Jianpan Huang; Xiongqi Han; Lin Chen; Xiang Xu; Peter C. M. van Zijl; Jiadi Xu; Kannie W. Y. Chan

Magnetization transfer contrast (MTC) suppressed relayed nuclear Overhauser enhancement (rNOE) imaging at 3 T

Jianpan Huang, Xiongqi Han, Lin Chen, Xiang Xu, Peter C. M. van Zijl, Jiadi Xu, Kannie W. Y. Chan

Department of Biomedical Engineering

Research output: Conference Papers › Abstract › peer-review

Abstract

Relayed nuclear Overhauser enhancement (rNOE) imaging indirectly detects the aliphatic groups of biomolecules and can be used to diagnose protein or lipid signals and related pathology involving such signals. Current rNOE imaging has been studied mainly on high-field MRI scanners (≥7T). When implementing the technique on low clinical MRI fields (≤3T), rNOE contrast is more obscured by semisolid magnetization transfer contrast (MTC) and water direct saturation (DS). We developed a pulsed-CEST/MT method at 3T MRI that can suppress MTC and DS efficiently, not compromising rNOE contrast.

Original language	English
Publication status	Published - Aug 2020
Event	ISMRM & SMRT Virtual Conference & Exhibition - Duration: 8 Aug 2020 → 14 Aug 2020

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Conference	ISMRM & SMRT Virtual Conference & Exhibition
Period	8/08/20 → 14/08/20

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@conference{8dbf60c57f9e45a3a9726b94f390f9e6,

title = "Magnetization transfer contrast (MTC) suppressed relayed nuclear Overhauser enhancement (rNOE) imaging at 3 T",

abstract = "Relayed nuclear Overhauser enhancement (rNOE) imaging indirectly detects the aliphatic groups of biomolecules and can be used to diagnose protein or lipid signals and related pathology involving such signals. Current rNOE imaging has been studied mainly on high-field MRI scanners (≥7T). When implementing the technique on low clinical MRI fields (≤3T), rNOE contrast is more obscured by semisolid magnetization transfer contrast (MTC) and water direct saturation (DS). We developed a pulsed-CEST/MT method at 3T MRI that can suppress MTC and DS efficiently, not compromising rNOE contrast.",

author = "Jianpan Huang and Xiongqi Han and Lin Chen and Xiang Xu and {van Zijl}, {Peter C. M.} and Jiadi Xu and Chan, {Kannie W. Y.}",

year = "2020",

month = aug,

language = "English",

note = "ISMRM & SMRT Virtual Conference & Exhibition ; Conference date: 08-08-2020 Through 14-08-2020",

}

TY - CONF

T1 - Magnetization transfer contrast (MTC) suppressed relayed nuclear Overhauser enhancement (rNOE) imaging at 3 T

AU - Huang, Jianpan

AU - Han, Xiongqi

AU - Chen, Lin

AU - Xu, Xiang

AU - van Zijl, Peter C. M.

AU - Xu, Jiadi

AU - Chan, Kannie W. Y.

PY - 2020/8

Y1 - 2020/8

N2 - Relayed nuclear Overhauser enhancement (rNOE) imaging indirectly detects the aliphatic groups of biomolecules and can be used to diagnose protein or lipid signals and related pathology involving such signals. Current rNOE imaging has been studied mainly on high-field MRI scanners (≥7T). When implementing the technique on low clinical MRI fields (≤3T), rNOE contrast is more obscured by semisolid magnetization transfer contrast (MTC) and water direct saturation (DS). We developed a pulsed-CEST/MT method at 3T MRI that can suppress MTC and DS efficiently, not compromising rNOE contrast.

AB - Relayed nuclear Overhauser enhancement (rNOE) imaging indirectly detects the aliphatic groups of biomolecules and can be used to diagnose protein or lipid signals and related pathology involving such signals. Current rNOE imaging has been studied mainly on high-field MRI scanners (≥7T). When implementing the technique on low clinical MRI fields (≤3T), rNOE contrast is more obscured by semisolid magnetization transfer contrast (MTC) and water direct saturation (DS). We developed a pulsed-CEST/MT method at 3T MRI that can suppress MTC and DS efficiently, not compromising rNOE contrast.

M3 - Abstract

T2 - ISMRM & SMRT Virtual Conference & Exhibition

Y2 - 8 August 2020 through 14 August 2020

ER -

Magnetization transfer contrast (MTC) suppressed relayed nuclear Overhauser enhancement (rNOE) imaging at 3 T

Abstract

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