Lysosome-targetable carbon dots for highly efficient photothermal/photodynamic synergistic cancer therapy and photoacoustic/two-photon excited fluorescence imaging

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Shaojing Zhao
  • Shuilin Wu
  • Qingyan Jia
  • Li Huang
  • Minhuan Lan
  • Pengfei Wang

Detail(s)

Original languageEnglish
Article number124212
Journal / PublicationChemical Engineering Journal
Volume388
Online published25 Jan 2020
Publication statusPublished - 15 May 2020

Abstract

Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT) holds great potential for efficient cancer therapy by inducing reactive oxygen species (ROS) or heat into tumor. Nevertheless, PDT or PTT suffers from some limitations, e.g., PTT requires long-time and high-power laser irradiation to generate enough heat, while the hypoxia microenvironment of tumor and the limit diffuse distance of ROS hamper the efficacy of oxygen-dependent PDT. Here we reported the carbon dots (CDs) which could simultaneously generate singlet oxygen (1O2), hydroxyl radical (OH[rad]), and heat under a 635 nm laser irradiation, with a 1O2 generation quantum yield of 5.7% and photothermal conversion efficiency of 73.5% (the highest thus far for CDs). Significantly, the CDs can selectively accumulate in lysosome, which is an ideal organelle for phototherapy because of its key role in sustaining cellular activity and stability. Moreover, the CDs present one-photon excited (OPE) and two-photon excited (TPE) fluorescence, and excellent photoacoustic (PA) imaging capability. Combining the good biocompatibility, the as-prepared CDs was served as multi-functional phototheranostic agent for synergistic PA/fluorescence imaging, and PDT/PTT.

Research Area(s)

  • Carbon dots, PDT, Photoacoustic imaging, PTT, Two-photon excited

Citation Format(s)

Lysosome-targetable carbon dots for highly efficient photothermal/photodynamic synergistic cancer therapy and photoacoustic/two-photon excited fluorescence imaging. / Zhao, Shaojing; Wu, Shuilin; Jia, Qingyan; Huang, Li; Lan, Minhuan; Wang, Pengfei; Zhang, Wenjun.

In: Chemical Engineering Journal, Vol. 388, 124212, 15.05.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal