TY - JOUR
T1 - Lutein production from microalgae
T2 - A review
AU - Fu, Yunlei
AU - Wang, Yinan
AU - Yi, Lanbo
AU - Liu, Jin
AU - Yang, Shufang
AU - Liu, Bin
AU - Chen, Feng
AU - Sun, Han
PY - 2023/5
Y1 - 2023/5
N2 - Lutein production from microalgae is a sustainable and economical strategy to offer the increasing global demands, but is still challenged with low lutein content at the high-cell density for commercial production. This review summarizes the suitable conditions for cell growth and lutein accumulation, and presents recent cultivation strategies to further improve lutein productivity. Light and nitrogen play critical roles in lutein biosynthesis that lead to the efficient multi-stage cultivation by increasing lutein content at the later stage. In addition, metabolic and genetic designs for carbon regulation and lutein biosynthesis are discussed at the molecule level. The in-situ lutein accumulation in fermenters by regulating carbon metabolism is considered as a cost-effective direction. Then, downstream processes are summarized for the efficient lutein recovery. Finally, challenges of current lutein production from microalgae are discussed. Meanwhile, potential solutions are proposed to improve lutein content and drive down costs of microalgal biomass. © 2023 Elsevier Ltd.
AB - Lutein production from microalgae is a sustainable and economical strategy to offer the increasing global demands, but is still challenged with low lutein content at the high-cell density for commercial production. This review summarizes the suitable conditions for cell growth and lutein accumulation, and presents recent cultivation strategies to further improve lutein productivity. Light and nitrogen play critical roles in lutein biosynthesis that lead to the efficient multi-stage cultivation by increasing lutein content at the later stage. In addition, metabolic and genetic designs for carbon regulation and lutein biosynthesis are discussed at the molecule level. The in-situ lutein accumulation in fermenters by regulating carbon metabolism is considered as a cost-effective direction. Then, downstream processes are summarized for the efficient lutein recovery. Finally, challenges of current lutein production from microalgae are discussed. Meanwhile, potential solutions are proposed to improve lutein content and drive down costs of microalgal biomass. © 2023 Elsevier Ltd.
KW - Carbon metabolism
KW - Downstream process
KW - Lutein production
KW - Microalgae
KW - Multi-stage cultivation
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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85150064455&origin=recordpage
U2 - 10.1016/j.biortech.2023.128875
DO - 10.1016/j.biortech.2023.128875
M3 - RGC 21 - Publication in refereed journal
C2 - 36921637
SN - 0960-8524
VL - 376
JO - Bioresource Technology
JF - Bioresource Technology
M1 - 128875
ER -