Abstract
Luminogenic bioorthogonal probes have emerged as very useful tools to visualize
biomolecules in complex cellular environments through “turn-on” emission and high
selectivity toward unique functional groups that minimize the background luminescence
of unreacted reagents. Recently, there has been a strong focus on the design of
luminogenic bioorthogonal probes that rely on the emission quenching effect of the
tetrazine moiety. Herein, we report the synthesis, characterization, and photophysical
studies of three novel luminogenic cyclometalated iridium(III) bis-tetrazine complexes.
The applications of these complexes as luminogenic double-clicking two-point binders
for the derivatives of a strained alkyne, bicyclo[6.1.0]non-4-yne (BCN) were examined.
The cellular uptake efficiency and (photo)cytotoxicity of the complexes were also
studied by ICP-MS and MTT assays, respectively.
| Original language | English |
|---|---|
| Publication status | Presented - 4 May 2019 |
| Event | 26th Symposium on Chemistry Postgraduate Research in Hong Kong - Chinese University of Hong Kong, Hong Kong, China Duration: 4 May 2019 → 4 May 2019 http://www.cuhk.edu.hk/chem/26thPostGradSymp/ http://www.cuhk.edu.hk/chem/26thPostGradSymp/uploads/1/1/2/5/112527129/26TH%20SYMPO%20CHEM%20POSTGRAD%20RES%20HK%202019-05-03%20v111.pdf |
Conference
| Conference | 26th Symposium on Chemistry Postgraduate Research in Hong Kong |
|---|---|
| Place | Hong Kong, China |
| Period | 4/05/19 → 4/05/19 |
| Internet address |