Luminescent transition metal polypyridine biotin complexes

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Wai-Ki Hui
  • Chi-Keung Chung
  • Keith Hing-Kit Tsang
  • Terence Kwok-Ming Lee
  • Dominic Chun-Ming Ng

Detail(s)

Original languageEnglish
Pages (from-to)53-65
Journal / PublicationJournal of the Chinese Chemical Society
Volume53
Issue number1
Publication statusPublished - Feb 2006

Abstract

In view of the fact that many transition metal complexes display intense and long-lived metal-to-ligand charge-transfer emission with a large Stokes' shift, we have incorporated biotin into a series of luminescent rhenium(I), iridium(III) and ruthenium(II) polypyridine complexes to form new probes for the protein avidin. All these luminescent transition metal polypyridine biotin complexes displayed enhanced emission intensities and extended lifetimes upon binding to avidin. These changes are closely related to the hydrophobic biotin-binding pockets of avidin and the increased rigidity of the local environment of the probes after they bind to the protein. We have exploited the characteristics of these luminescent transition metal biotin complexes in the development of various assays.

Research Area(s)

  • Biotin, Iridium(III), Luminescence, Rhenium(I), Ruthenium(II)

Citation Format(s)

Luminescent transition metal polypyridine biotin complexes. / Lo, Kenneth Kam-Wing; Hui, Wai-Ki; Chung, Chi-Keung; Tsang, Keith Hing-Kit; Lee, Terence Kwok-Ming; Ng, Dominic Chun-Ming.

In: Journal of the Chinese Chemical Society, Vol. 53, No. 1, 02.2006, p. 53-65.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review