Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane (POSS) Core and Iridium(III) Polypyridine Arms : Synthesis, Aggregation Induced Emission, Cellular Uptake, and Bioimaging Studies

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)10633-10641
Journal / PublicationChemistry - A European Journal
Volume25
Issue number45
Early online date26 Apr 2019
Publication statusPublished - 9 Aug 2019

Abstract

A new class of luminescent molecular hybrids in which eight cyclometalated iridium(III) polypyridine complexes are grafted onto a polyhedral oligomeric silsesquioxane (POSS) unit [POSS-{Ir(N^C)2(py-im)}8](PF6)8 [py-im=pyridine imine; HN^C=N-phenylpyrazole (Hppz) (1 a), 2-phenylpyridine (Hppy) (2 a), 2-phenylquinoline (Hpq) (3 a)] were synthesized and characterized. On photoexcitation, the complexes showed intense and long-lived orange-red to red emission in fluid solutions at room temperature and in low-temperature glasses. The photophysical properties including aggregation-induced emission and biological properties of these complexes were studied and compared with those of their POSS-free counterparts [Ir(N^C)2(py-im)](PF6) [HN^C=Hppz (1 b), Hppy (2 b), Hpq (3 b)]. The (photo)cytotoxicity of the complexes was examined by the MTT assay, and their cellular uptake and intracellular localization were investigated by inductively coupled plasma-mass spectrometry and laser-scanning confocal microscopy.

Research Area(s)

  • aggregation, imaging agents, iridium, luminescence, silsesquioxanes

Citation Format(s)

Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane (POSS) Core and Iridium(III) Polypyridine Arms : Synthesis, Aggregation Induced Emission, Cellular Uptake, and Bioimaging Studies. / Zhu, Jing-Hui; Tang, Ben Zhong; Lo, Kenneth Kam-Wing.

In: Chemistry - A European Journal, Vol. 25, No. 45, 09.08.2019, p. 10633-10641.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review