Low-modulus Mg/PCL hybrid bone substitute for osteoporotic fracture fixation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Hoi Man Wong
  • Shuilin Wu
  • Keith D.K. Luk
  • Kenneth M.C. Cheung
  • Kelvin W.K. Yeung

Detail(s)

Original languageEnglish
Pages (from-to)7016-7032
Journal / PublicationBiomaterials
Volume34
Issue number29
Publication statusPublished - Sep 2013

Abstract

In this paper, we describe a new biodegradable composite composed of polycaprolactone and magnesium. Incorporation of magnesium micro-particles into the polycaprolactone matrix yields mechanical properties close to those of human cancellous bone, and invitro studies indicate that the silane-coated Mg/PCL composites have excellent cytocompatibility and osteoblastic differentiation properties. The bioactivity of the composites is manifested by the formation of calcium and phosphate after immersion in simulated body fluids. The bulk mechanical properties can be maintained for 2 months before obvious degradation takes place. The invivo animal study reveals a larger amount of new bone formation on the silane-coated Mg/PCL composites compared to conventional PMMA and pure polycaprolactone and our results suggest potential clinical applications of the sliane-coated Mg/PCL composites. © 2013 Elsevier Ltd.

Research Area(s)

  • Bioactive, Biodegradable, Low modulus, Magnesium, Polycaprolactone

Citation Format(s)

Low-modulus Mg/PCL hybrid bone substitute for osteoporotic fracture fixation. / Wong, Hoi Man; Wu, Shuilin; Chu, Paul K.; Cheng, Shuk Han; Luk, Keith D.K.; Cheung, Kenneth M.C.; Yeung, Kelvin W.K.

In: Biomaterials, Vol. 34, No. 29, 09.2013, p. 7016-7032.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review