Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma

Yabo Jiang; Yongzhen Tao; Xiuping Zhang; Xubiao Wei; Min Li; Xuxiao He; Bin Zhou; Weixing Guo; Huiyong Yin; Shuqun Cheng

doi:10.1002/1878-0261.12846

Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma

Yabo Jiang
, Yongzhen Tao
, Xiuping Zhang
, Xubiao Wei
, Min Li
, Xuxiao He
, Bin Zhou
, Weixing Guo
, Huiyong Yin^*
, Shuqun Cheng^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

13 Citations (Scopus)

35 Downloads (CityUHK Scholars)

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Here, we identified that increased miR-23a expression in HCC tissues was associated with worse survival. More importantly, we found that STAT5A was a target of miR-23a, whose levels significantly decreased in tumor tissues. Stable expression of STAT5A in Huh7 cells suppressed glucose metabolism and tumor growth. Finally, this study showed that increased miR-23a negatively regulated STAT5A, which further activated AKT signaling to enable rapid metabolism for accelerated tumor growth in HCC. Taken together, our results demonstrated that the miR-23a-STAT5A-AKT signaling pathway is critical to alter glucose metabolism in HCC and may offer new opportunities for effective therapy. © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

Original language	English
Pages (from-to)	710-724
Journal	Molecular Oncology
Volume	15
Issue number	2
Online published	6 Nov 2020
DOIs	https://doi.org/10.1002/1878-0261.12846
Publication status	Published - Feb 2021
Externally published	Yes

Funding

This work was supported by the Key Project of Natural Science Foundations of China (No:81730097), Shanghai Sailing Program (20YF1459700), and the Project of Natural Science Foundations of China (No:82072618).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

AKT
glucose metabolism
hepatocellular carcinoma
miR-23a
STAT5A
tumor growth

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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@article{001c180ddad8486ea0bc1042bc33e0e5,

title = "Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma",

abstract = "Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Here, we identified that increased miR-23a expression in HCC tissues was associated with worse survival. More importantly, we found that STAT5A was a target of miR-23a, whose levels significantly decreased in tumor tissues. Stable expression of STAT5A in Huh7 cells suppressed glucose metabolism and tumor growth. Finally, this study showed that increased miR-23a negatively regulated STAT5A, which further activated AKT signaling to enable rapid metabolism for accelerated tumor growth in HCC. Taken together, our results demonstrated that the miR-23a-STAT5A-AKT signaling pathway is critical to alter glucose metabolism in HCC and may offer new opportunities for effective therapy. {\textcopyright} 2020 The Authors. Published by FEBS Press and John Wiley \& Sons Ltd.",

keywords = "AKT, glucose metabolism, hepatocellular carcinoma, miR-23a, STAT5A, tumor growth",

author = "Yabo Jiang and Yongzhen Tao and Xiuping Zhang and Xubiao Wei and Min Li and Xuxiao He and Bin Zhou and Weixing Guo and Huiyong Yin and Shuqun Cheng",

year = "2021",

month = feb,

doi = "10.1002/1878-0261.12846",

language = "English",

volume = "15",

pages = "710--724",

journal = "Molecular Oncology",

issn = "1574-7891",

publisher = "John Wiley \& Sons",

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}

TY - JOUR

T1 - Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma

AU - Jiang, Yabo

AU - Tao, Yongzhen

AU - Zhang, Xiuping

AU - Wei, Xubiao

AU - Li, Min

AU - He, Xuxiao

AU - Zhou, Bin

AU - Guo, Weixing

AU - Yin, Huiyong

AU - Cheng, Shuqun

PY - 2021/2

Y1 - 2021/2

N2 - Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Here, we identified that increased miR-23a expression in HCC tissues was associated with worse survival. More importantly, we found that STAT5A was a target of miR-23a, whose levels significantly decreased in tumor tissues. Stable expression of STAT5A in Huh7 cells suppressed glucose metabolism and tumor growth. Finally, this study showed that increased miR-23a negatively regulated STAT5A, which further activated AKT signaling to enable rapid metabolism for accelerated tumor growth in HCC. Taken together, our results demonstrated that the miR-23a-STAT5A-AKT signaling pathway is critical to alter glucose metabolism in HCC and may offer new opportunities for effective therapy. © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

AB - Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Here, we identified that increased miR-23a expression in HCC tissues was associated with worse survival. More importantly, we found that STAT5A was a target of miR-23a, whose levels significantly decreased in tumor tissues. Stable expression of STAT5A in Huh7 cells suppressed glucose metabolism and tumor growth. Finally, this study showed that increased miR-23a negatively regulated STAT5A, which further activated AKT signaling to enable rapid metabolism for accelerated tumor growth in HCC. Taken together, our results demonstrated that the miR-23a-STAT5A-AKT signaling pathway is critical to alter glucose metabolism in HCC and may offer new opportunities for effective therapy. © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

KW - AKT

KW - glucose metabolism

KW - hepatocellular carcinoma

KW - miR-23a

KW - STAT5A

KW - tumor growth

UR - https://www.scopus.com/pages/publications/85096767436

UR - https://www.scopus.com/pages/publications/85096767436#tab=impact

U2 - 10.1002/1878-0261.12846

DO - 10.1002/1878-0261.12846

M3 - RGC 21 - Publication in refereed journal

C2 - 33155364

SN - 1574-7891

VL - 15

SP - 710

EP - 724

JO - Molecular Oncology

JF - Molecular Oncology

IS - 2

ER -

Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma

Abstract

Funding

UN SDGs

Research Keywords

Publisher's Copyright Statement

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