Long-term antibacterial characteristics and cytocompatibility of titania nanotubes loaded with Au nanoparticles without photocatalytic effects

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

22 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)230-237
Journal / PublicationApplied Surface Science
Volume414
Online published23 Apr 2017
Publication statusPublished - 31 Aug 2017

Abstract

Au nanoparticles (NPs) can endow titania nanotubes (Au@TiO2-NT) with light-independent antibacterial properties which bode well for in vivo application because of the dark environment inside tissues. In this work, the long-term antibacterial bactericidal properties and cytocompatibility of Au@TiO2-NT without photocatalytic effects are studied in details. The materials exhibit MC3T3-E1 osteoblasts on Au@TiO2-NT reveal cytocompatibility comparable to that of TiO2-NT. No reactive oxygen species (ROS) are detected from either the antibacterial effects against Staphylococcus aureus according to antibacterial tests carried out for a total time of 21 days, which are normally long enough for early stage tissue healing after surgery. In addition, adhesion and proliferation of bacteria or MC3T3-E1 cells cultured on the Au@TiO2-NT surface. The absence of ROS, long-term antibacterial properties, and cytocompatibility make Au@TiO2-NT promising biomaterials in orthopedic devices and implants.

Research Area(s)

  • Au-loaded titania nanotubes, Cytocompatibility, Long-term antibacterial properties, ROS-free

Citation Format(s)

Long-term antibacterial characteristics and cytocompatibility of titania nanotubes loaded with Au nanoparticles without photocatalytic effects. / Wang, Guomin; Feng, Hongqing; Jin, Weihong; Gao, Ang; Peng, Xiang; Li, Wan; Wu, Hao; Li, Zhou; Chu, Paul K.

In: Applied Surface Science, Vol. 414, 31.08.2017, p. 230-237.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review