Long term potentiation, but not depression, in interlamellar hippocampus CA1

Duk-gyu Sun; Hyeri Kang; Hannah Tetteh; Junfeng Su; Jihwan Lee; Sung-Won Park; Jufang He; Jihoon Jo; Sungchil Yang; Sunggu Yang

doi:10.1038/s41598-018-23369-4

Author(s)

Duk-gyu Sun
Hyeri Kang
Jihwan Lee
Sung-Won Park
Jihoon Jo
Sunggu Yang

Related Research Unit(s)

Department of Biomedical Sciences

Detail(s)

Original language	English
Article number	5187
Journal / Publication	Scientific Reports
Volume	8
Online published	26 Mar 2018
Publication status	Published - 2018

Link(s)

DOI	DOI https://doi.org/10.1038/s41598-018-23369-4 Final Published version
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Attachment(s)	Documents 21421054.pdf Final Published version, 3.2 MB, PDF Publisher's Copyright Statement This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85044545850&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(0fc2246a-af57-4be1-bad2-848feab8e821).html

Abstract

Synaptic plasticity in the lamellar CA3 to CA1 circuitry has been extensively studied while interlamellar CA1 to CA1 connections have not yet received much attention. One of our earlier studies demonstrated that axons of CA1 pyramidal neurons project to neighboring CA1 neurons, implicating information transfer along a longitudinal interlamellar network. Still, it remains unclear whether long-term synaptic plasticity is present within this longitudinal CA1 network. Here, we investigate long-term synaptic plasticity between CA1 pyramidal cells, using in vitro and in vivo extracellular recordings and 3D holography glutamate uncaging. We found that the CA1-CA1 network exhibits NMDA receptor-dependent long-term potentiation (LTP) without direction or layer selectivity. By contrast, we find no significant long-term depression (LTD) under various LTD induction protocols. These results implicate unique synaptic properties in the longitudinal projection suggesting that the interlamellar CA1 network could be a promising structure for hippocampus-related information processing and brain diseases.