Localised heating of tumours utilising injectable magnetic nanoparticles for hyperthermia cancer therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

43 Scopus Citations
View graph of relations

Author(s)

  • H. Y. Tseng
  • G. B. Lee
  • C. Y. Lee
  • Y. H. Shih
  • X. Z. Lin

Detail(s)

Original languageEnglish
Pages (from-to)46-54
Journal / PublicationIET Nanobiotechnology
Volume3
Issue number2
Publication statusPublished - 2009
Externally publishedYes

Abstract

This study reports an investigation of hyperthermia cancer therapy utilising an alternating magnetic field to induce a localised temperature increase on tumours by using injectable magnetic nanoparticles. In-vitro and in-vivo experiments represent the feasibility of hyperthermia cancer therapy. A feedback temperature control system was first developed to keep the nanoparticles at a constant temperature to prevent overheating in the tumours such that a safer and more precise cancer therapy becomes feasible. By using the feedback temperature control system, magnetic nanoparticles can be heated up to the specific constant temperatures, 37, 40, 42, 45, 46 and 47°C, respectively, with a variation less than 0.2°C. With this approach, the in-vitro survival rate of tumour cells at different temperatures can be systematically explored. It was experimentally found that the survival rate of cancer cells can be greatly reduced while CT-26 cancer cells were heated above 45°C. Besides, localised temperatures increase as high as 59.5°C can be successfully generated in rat livers by using the proposed method. Finally, complete regression of tumour was achieved. The developed method used injectable magnetic nanoparticles and may provide a promising approach for hyperthermia cancer therapy. © The Institution of Engineering and Technology 2009.

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.